Fusobacterium nucleatum. ¿un patógeno periodontal promotor de carcinogénesis colorrectal? / Fusobacterium nucleatum. is this periodontal pathogen a promoter of colorectal carcinogenesis?
Rev. ADM
; 73(6): 280-285, nov.-dic. 2016. ilus
Article
in Es
| LILACS
| ID: biblio-869337
Responsible library:
AR29.1
RESUMEN
El Fusobacterium nucleatum es una bacteria anaerobia Gram negativa,es un residente común en el biofi lm oral y se ha encontrado una estrechaasociación entre las fusobacterias y las periodontitis. El Fusobacteriumnucleatum se ha asociado con el cáncer colorrectal, pero la causalidad y el mecanismo subyacente aún no se han establecido. La microbiota intestinal humana tiene un papel reconocido en el cáncer colorrectal. Se ha encontrado que el Fn se adhiere, invade, e induce respuestas inflamatorias oncogénicas que estimulan el crecimiento de las células de cáncer colorrectal a través de un factor de la adhesina FadA.
ABSTRACT
The anaerobic, Gram-negative bacterial species Fusobacterium nucleatumis common in oral biofi lm and the association between it andperiodontitis is well-established. Fusobacterium nucleatum has beenassociated with colorectal cancer, though causality and the underlyingmechanism have yet to be determined. The role of the human gutmicrobiota in colorectal cancer has been acknowledged. Fusobacteriumnucleatum has been found to adhere to, invade, and induce oncogenicand infl ammatory responses that stimulate the growth of colorectalcancer cells through its unique FadA adhesin.
Key words
Full text:
1
Index:
LILACS
Main subject:
Periodontal Diseases
/
Colorectal Neoplasms
/
Fusobacterium nucleatum
/
Dysbiosis
Type of study:
Etiology_studies
Limits:
Humans
Language:
Es
Journal:
Rev. ADM
Journal subject:
ODONTOLOGIA
/
ORTODONTIA
Year:
2016
Type:
Article