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Neurocriptococose por Cryptococcus gattii resistente a fluconazol em imunocompetente / Fluconazole-resistant neurocryptococcosis caused by Cryptococcus gattii in immunocompetent individuals: case report
Lima, Angela Carosi Augusto Galvão de Souza; Ishiwaki Jr, Shizuo; Maksymczuk, Daniella de Rezende Duarte.
  • Lima, Angela Carosi Augusto Galvão de Souza; Hospital das Clínicas Luzia de Pinho Melo. Mogi das Cruzes, SP. BR
  • Ishiwaki Jr, Shizuo; Hospital das Clínicas Luzia de Pinho Melo. Mogi das Cruzes, SP. BR
  • Maksymczuk, Daniella de Rezende Duarte; Universidade de Mogi das Cruzes. Mogi das Cruzes, SP. BR
Rev. Soc. Bras. Clín. Méd ; 15(2): 124-126, 20170000. ilus
Article in Portuguese | LILACS | ID: biblio-875612
Responsible library: BR1610.9
RESUMO
A criptococose é uma doença fúngica sistêmica causada por Cryptococcus neoformans, que acomete principalmente indivíduos imunocomprometidos, podendo eventualmente acometer imunocompetentes. Existem duas variedades da espécie (neoformans e gattii), com características diferentes, mas clinicamente semelhantes, sendo possível sua distinção apenas por do teste de identificação da espécie. O tratamento preconizado é constituído por anfotericina B e fluconazol endovenosos, com duração de meses, existindo pouco relato na literatura sobre resistência à terapêutica habitual ou tratamento alternativo. Neste trabalho, é relatado um caso de neurocriptococose por C. gattii resistente a fluconazol em imunocompetente, no qual foi realizada anfotericina B endovenosa associada a intratecal sem sucesso, evoluindo o paciente a óbito por provável complicações da hidrocefalia obstrutiva.(AU)
ABSTRACT
Cryptococcosis is a systemic fungal disease caused by Cryptococcus neoformans, which primarily affects immunocompromised individuals, but may occasionally affect immunocompetent individuals. There are two varieties of the species, with different, but clinically similar characteristics, with their distinction being possible only through the species identification test. The recommended treatment consists of intravenous amphotericin B and fluconazole, for some months. There are few reports in the literature on resistance to standard therapy, or an alternative treatment. In this study, we describe a case of fluconazole-resistant neurocryptococcosis by Cryptococcus gattii in immunocompetent individuals, who unsuccessfully received intravenous and intrathecal amphotericin B , with the patient progressing to death from probable complications of obstructive hydrocephalus.(AU)
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Full text: Available Index: LILACS (Americas) Main subject: Fluconazole / Amphotericin B / Meningitis, Cryptococcal Type of study: Case report Limits: Adult / Humans / Male Language: Portuguese Journal: Rev. Soc. Bras. Clín. Méd Journal subject: Therapeutics Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital das Clínicas Luzia de Pinho Melo/BR / Universidade de Mogi das Cruzes/BR

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Full text: Available Index: LILACS (Americas) Main subject: Fluconazole / Amphotericin B / Meningitis, Cryptococcal Type of study: Case report Limits: Adult / Humans / Male Language: Portuguese Journal: Rev. Soc. Bras. Clín. Méd Journal subject: Therapeutics Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital das Clínicas Luzia de Pinho Melo/BR / Universidade de Mogi das Cruzes/BR