Analysis of MMP-3 polymorphism in osseointegrated implant failure
Braz. j. oral sci
;
15(4): 304-307, Oct.-Dec. 2016. tab
Article
in English
| LILACS, BBO
| ID: biblio-875864
ABSTRACT
Polymorphisms in matrix metalloproteinases (MMPs) genes have been associated with several pathologies, including dental implant loss. MMP-3 is crucial to the connective tissue remodeling process. The objective of this study was to investigate the possible relationship between -1612 MMP-3 polymorphism and the early implant failure. A sample of 240 non-smokers was divided: test group 120 patients with one or more early failed implants and control group 120 patients with one or more healthy implants. Genomic DNA from oral mucosa was analyzed by PCR-RFLP. No association of early implant loss with genotypes and alleles of the -1612 polymorphism in MMP-3 were found by the Chi-squared test. Only the presence of the -1612 polymorphism of MMP-3 is not a genetic risk factor for early loss of implants (AU)
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Risk Factors
/
Matrix Metalloproteinase 3
/
Metalloproteases
Type of study:
Etiology study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. oral sci
Journal subject:
Dentistry
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculty Avantis of Balneário Camboriú/BR
/
University Federal of Paraná/BR
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