Glutamine metabolism and its effects on immune response: molecular mechanism and gene expression
Nutrire Rev. Soc. Bras. Aliment. Nutr
;
41: 1-10, Dec. 2016. ilus
Article
in English
| LILACS
| ID: biblio-880562
ABSTRACT
This article aims to review glutamine metabolism and its effects on the immune response. Selected topics are addressed, particularly the effect of glutamine on cell survival and proliferation, as well as its importance in some biochemical pathways. The impact of glutamine on muscle, intestine, and liver metabolism are described, and a special section about glutamine regulation of the immune response is included. In this context, the modulation of glutamine on relevant signaling pathways as nuclear factor kappa B (NF-kB), mitogen-activated protein kinases (MAPKs), and heat shock protein and the influence of this amino acid on cell migration and adhesion molecules are highlighted. Some important immune response pathways modulated by glutamine were described as its action incritically ill patients. In summary, this review describes some important actions of glutamine, and a range of reactions and modulatory effects in different organs, which may inform new therapeutic strategies. However, further studies are necessary to provide information about glutamine use, especially about situations in which it can be better used as well as fine-tuning dose and administration.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
NF-kappa B
/
Glutamine
Limits:
Animals
Language:
English
Journal:
Nutrire Rev. Soc. Bras. Aliment. Nutr
Journal subject:
Nutritional Sciences
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of São Paulo/BR
/
University of São Paulo,/BR
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