The influence of obesity by a diet high in saturated fats and carbohydrates balance in the manifestation of systemic complications and comorbidities
Nutrire Rev. Soc. Bras. Aliment. Nutr
;
42: 1-6, Dec. 2017. tab
Article
in English
| LILACS
| ID: biblio-881175
ABSTRACT
BACKGROUND: The aim of this study is to test the hypothesis that obesity induced by a diet rich in saturated fats and balanced in carbohydrates is associated with the development of systemic complications and comorbidities. METHODS: Thirty-seven 60-day-old male Wistar rats were randomized into two groups: control (C,n= 18, standard diet) and obese (OB, n= 19, high-saturated fat diet), for 33 weeks. Nutritional profile: food and caloric intake, feed efficiency, body weight, and adiposity index. Complications: in plasma were analyzed dyslipidemia, insulin resistance (HOMA-IR), glucose intolerance, hyperleptinemia, hyperinsulinemia, plasmatic C-reactive protein (CRP), interleukin-6(IL-6), and tumor necrosis factor-alpha (TNF-α); in the myocardial and epididymal adipose tissue were assessed IL-6and TNF-α. Comorbidities: diabetes mellitus and systemic blood pressure (SBP). Student'sttest, ANOVA, and Bonferroni P< 0.05.RESULTS:The final body weight, feed efficiency, and adiposity index were higher in OB group than in control; although food intake was lower in OB group, caloric intake was similar in both groups. Specific parameters, such as LDL, cholesterol, triglycerides, HOMA-IR, CRP, TNF-αin epididymal adipose tissue, and IL-6 in the myocardium, were higher in obese rats than in controls. SBP, baseline glucose, and glucose after 2 h of overload were significantly increased in OB group; however, the severity was not enough to classify the animals as diabetic and hypertensive. CONCLUSION: Obesity induced by a diet high in saturated fatty acids with balanced carbohydrates for 33 weeks in Wistar rats was effective in triggering complications but unable to develop comorbidities.
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Index:
LILACS (Americas)
Main subject:
Comorbidity
/
Feeding Behavior
/
Obesity
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Nutrire Rev. Soc. Bras. Aliment. Nutr
Journal subject:
Nutritional Sciences
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
São Paulo State University/BR
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