Alternative animal model for studies of total skin thickness burns
Acta cir. bras
;
32(10): 836-842, Oct. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-886171
ABSTRACT
Abstract Purpose:
To present an alternative experimental model of third degree burn of easy reproducibility.Methods:
Eighteen male Wister rats were randomly divided into three groups, 6 of which were allocated to each group. A soldering iron coupled to an aluminum plate was used to produce burn, at a temperature of 150ºC, with different exposure times per group. Group 5 (G5) animals were burned at 150°C with exposure time of 5 seconds; Group 10 (G10) the animals were burned at 150°C with exposure time of 10 seconds and group 15 (G15) the animals were burned at 150°C with exposure time of 15 seconds.Results:
Histopathological analyzes showed that all three groups had similar morphological characteristics, with total thickness involvement.Conclusion:
The technique is effective to reproduce a third degree burn and suggests the temperature of 150ºC with 5 seconds of exposure in order to minimize the risks to the animals.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Skin
/
Burns
/
Disease Models, Animal
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de São Carlos/BR
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