Evaluation of silybum marinaum efficacy on University of Wisconsin and histidine-tryptophan-ketoglutarate solutions latter the damage of the perfused liver
Acta cir. bras
;
32(6): 407-417, June 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-886210
ABSTRACT
Abstract Purpose:
To investigate the hepatoprotective and antioxidant effeicacies of Silybum marianum's (silymarin, S) on University of Wisconsin (UW) and histidinetryptophan-ketoglutarate (HTK) preservation solutions.Methods:
Thirty two Wistar albino adult male rats were used. Group 1 UW group, Group 2 UW + Silymarin group(S), Group 3 HTK group, Group 4 HTK + silymarin group (S), respectively. Silymarin was enforced intraperitoneally before the surgery. Biopsies were enforced in 0, 6 and 12.hours to investigate.Results:
Biochemical parameters examined in alanine aminotransferase (ALT), furthermore superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in rats were also evaluated. Detected histopathological changings were substantially declining in the groups that received silymarin, cellular damage was decreased significantly in HTK + Silymarin group, according to other groups. It has been identified as the most effective group was HTK + silymarin group in evaluation of ALT, electron microscopic results, also decreased MDA and elevated in SOD, and CAT activity. Caspase 3 analysis showed a substantial lower apoptosis ratio in the silymarin groups than in the non-performed groups (p<0.05).Conclusion:
Histidinetryptophan-ketoglutarate+silymarin group provides better hepatoprotection than other groups, by decreasing the hepatic pathologic damage, delayed changes that arise under cold ischemic terms.
Full text:
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Index:
LILACS (Americas)
Main subject:
Silymarin
/
Organ Preservation Solutions
/
Protective Agents
/
Chemical and Drug Induced Liver Injury
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2017
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Kahramanmaras Sütçü Imam University/TR
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