The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
Acta cir. bras
;
32(7): 559-567, July 2017. graf
Article
in English
| LILACS
| ID: biblio-886218
ABSTRACT
Abstract Purpose:
To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR).Methods:
Thirty rats were assigned to 5 groups (N=6) (CG) no clamping of the superior mesenteric artery (90 min.); (IR-SS) saline + ischemia (30 min.) + reperfusion (60 min.); (IR-PTX) PTX + ischemia (30min.) + reperfusion (60 min.); (IPC-IR-SS) 5 min. of ischemia + 5 minutes of reperfusion (IPC) + saline + ischemia (30 min.) + reperfusion (60 min.); (IPC-IR-PTX ) 5 min. of ischemia + 5 min. of reperfusion (IPC) + PTX + 30 min. of I + 60 minutes of R.Results:
The IR-PTX, IPC-IR-SS and IPC-IR-PTX groups had significantly lower scores of mucosa damage than the IR-SS group. IR-PTX group showed higher scores than the IPC-IR-PTX group, in accordance with the hypothesis of a favorable effect of IPC alone or in association with PTX. Additionally, IPC-IR-SS had a higher damage score than the IPC-IR-PTX. The villi height and crypt depth were similar in all groups. The villi height in the IR-SS was significantly lower.Conclusion:
Ischemic preconditioning or pentoxifylline alone protect the intestinal mucosa from ischemia/reperfusion injury. However, they do not have a synergistic effect when applied together.
Full text:
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Index:
LILACS (Americas)
Main subject:
Pentoxifylline
/
Vasodilator Agents
/
Reperfusion Injury
/
Intestines
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal da Grande Dourados/BR
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