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Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy?
Alves, Ana Karina Soares; Lanzoni, Valéria; Fuziy, Rogério Aoki; Franco, Rita Maria Aparecida Monteiro Moura; Maeda, Carlos Toshinori; Lopes Filho, Gaspar de Jesus; Linhares, Marcelo Moura.
  • Alves, Ana Karina Soares; Universidade Federal de São Paulo. Postgraduate Program in Interdisciplinary Surgical Sciences. BR
  • Lanzoni, Valéria; Universidade Federal de São Paulo. Postgraduate Program in Interdisciplinary Surgical Sciences. BR
  • Fuziy, Rogério Aoki; Universidade Federal de São Paulo. Postgraduate Program in Interdisciplinary Surgical Sciences. BR
  • Franco, Rita Maria Aparecida Monteiro Moura; Universidade Federal de São Paulo. Postgraduate Program in Interdisciplinary Surgical Sciences. BR
  • Maeda, Carlos Toshinori; Universidade Federal de São Paulo. Postgraduate Program in Interdisciplinary Surgical Sciences. BR
  • Lopes Filho, Gaspar de Jesus; Universidade Federal de São Paulo. Postgraduate Program in Interdisciplinary Surgical Sciences. BR
  • Linhares, Marcelo Moura; Universidade Federal de São Paulo. Postgraduate Program in Interdisciplinary Surgical Sciences. BR
Acta cir. bras ; 32(7): 515-522, July 2017. tab, graf
Article in English | LILACS | ID: biblio-886219
ABSTRACT
Abstract

Purpose:

To evaluate the effects of mesenchymal stem cells on liver regeneration in rats following a 70% hepatectomy.

Methods:

Forty rats were subjected to 70% hepatectomy and then ~106 mesenchymal stem cells (test group), or saline solution (control group), were infused into their livers via the portal vein. Each treatment group was divided into early and late subgroups (euthanized 3 d and 5 d following the operation, respectively). Group comparisons of Albumin, aminotransaminases (AST, ALT), and Alcaline Phosphatase (AP) levels, proliferative index (ki-67+ straining), and mitotic cell counts were conducted.

Results:

No significant differences in liver regeneration rate, number of mitoses, proliferative index, or serum levels of albumin, AST, or AP were observed. ALT levels were higher in the test group than in the control group (p<.05).

Conclusions:

Mesenchymal stem-cell therapy did not improve liver regeneration rate 3 d or 5 d after 70% hepatectomy in rats. Likewise, the therapy appeared not to affect liver function, proliferative index, or number of mitoses significantly.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Mesenchymal Stem Cell Transplantation / Hepatectomy / Liver Regeneration Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Mesenchymal Stem Cell Transplantation / Hepatectomy / Liver Regeneration Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR