Experimental study of peripheral-blood pro-surfactant protein B for screening non-small cell lung cancer
Acta cir. bras
;
32(7): 568-575, July 2017. tab
Article
in English
| LILACS
| ID: biblio-886221
ABSTRACT
Abstract Purpose:
To evaluate the possibility of using peripheral-blood presurfactant protein B (Pro-SFTPB) for screening non-small cell lung cancer (NSCLC).Methods:
A total of 873 healthy volunteers and 165 lung cancer patients hospitalized in the Fifth People's Hospital of Dalian were tested Pro-SFTPB once every half year from January 2014 to September 2015. The healthy volunteers were also conducted spiral computed tomography (CT) examination once every year. The data were then com-pared and statistically analyzed.Results:
The positive expression rate of Pro-SFTPB in NSCLC was significantly higher than that in healthy volunteers, and significantly higher in lung adenocarcinoma than in squamous cell carcinoma; additionally, the expression rate was increased with the in-crease of smoking index, and the intergroup differences showed statistical signifi-cance (p≤0.05). The positive rate of newly diagnosed lung cancer was 29.55%, higher than healthy volunteers (22.34%), but there was no significant difference (p>0.05).Conclusion:
Pro-SFTPB is over expressed in non-small cell lung cancer, especially in lung adeno-carcinoma, but it can't be used as a clinical screening tool for lung cancer.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Protein Precursors
/
Carcinoma, Non-Small-Cell Lung
/
Pulmonary Surfactant-Associated Proteins
/
Lung Neoplasms
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2017
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
People's Hospital of Dalian/CN
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