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Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study
Khorshidi, Hamid Reza; Kasraianfard, Amir; Derakhshanfar, Amir; Rahimi, Siavash; Sharifi, Ali; Makarchian, Hamid Reza; Ghorbanpoor, Manoochehr; Javadi, Seyed Mohammad Reza.
  • Khorshidi, Hamid Reza; Hamadan University. Department of Surgery, Medical Sciences. IR
  • Kasraianfard, Amir; Hamadan University. Department of Surgery, Medical Sciences. IR
  • Derakhshanfar, Amir; Hamadan University. Department of Surgery, Medical Sciences. IR
  • Rahimi, Siavash; Hamadan University. Department of Surgery, Medical Sciences. IR
  • Sharifi, Ali; Hamadan University. Department of Surgery, Medical Sciences. IR
  • Makarchian, Hamid Reza; Hamadan University. Department of Surgery, Medical Sciences. IR
  • Ghorbanpoor, Manoochehr; Hamadan University. Department of Surgery, Medical Sciences. IR
  • Javadi, Seyed Mohammad Reza; Hamadan University. Department of Surgery, Medical Sciences. IR
Acta cir. bras ; 32(8): 626-632, Aug. 2017. tab, graf
Article in English | LILACS | ID: biblio-886226
ABSTRACT
Abstract

Purpose:

To evaluate the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing of postoperative surgical adhesion formation.

Methods:

Forty male Wistar rats were randomly assigned into five groups with eight rats in each group including control, hyaluronate, sesame, honey and silver groups. After two weeks the animals underwent laparotomy and were evaluated by two different blinded surgeons for severity of adhesions based on the two different classification scoring systems including Nair classification and cumulative adhesion scoring scale.

Results:

The scores of severity of adhesions in the hyaluronate and sesame groups were significantly lower than the control group based on the Nair classification (both P-values = 0.02), however based on the cumulative adhesion scoring scale just the score of severity of adhesions in the hyaluronate group was significantly lower than the control group (P-value = 0.02). In the hyaluronate group the severity of adhesions was decreased by 48% based on the cumulative adhesion scoring scale.

Conclusions:

Sodium hyaluronate and sesame oil may have a significant effect in preventing postoperative surgical adhesion formation.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Postoperative Complications / Silver / Sesame Oil / Metal Nanoparticles / Honey / Hyaluronic Acid Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Iran Institution/Affiliation country: Hamadan University/IR

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Full text: Available Index: LILACS (Americas) Main subject: Postoperative Complications / Silver / Sesame Oil / Metal Nanoparticles / Honey / Hyaluronic Acid Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Iran Institution/Affiliation country: Hamadan University/IR