A study on reducing the absorption of lidocaine from the airway in cats
Acta cir. bras
; Acta cir. bras;32(8): 662-672, Aug. 2017. tab, graf
Article
in En
| LILACS
| ID: biblio-886229
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To determine if the combination of lidocaine with epinephrine or gamma globulin would decrease the rate or reduce the amount of local absorption of lidocaine through the airway.Methods:
Twenty adult male cats were randomly and evenly distributed into four groups 1) Group LG lidocaine administered with gamma globulin; 2) Group LS lidocaine administered with physiological saline); 3) Group LE lidocaine administered with epinephrine; 4) Group C control group. Invasive blood pressure, heart rate, and concentration of lidocaine were recorded before and after administration.Results:
The peak of plasma concentrations appeared difference (Group LG 1.39 ± 0.23 mg/L; Group LS 1.47 ± 0.29 mg/L and Group LE 0.99 ± 0.08 mg/L). Compared to Group C, there were significant differences in the average heart rate of Groups LG, LS, and LE (P < 0.05). The average systolic blood pressures were significantly different when each group was compared to Group C (P < 0.05). The biological half-life, AUC0-120, peak time, and half-life of absorption among the three groups have not presented statistically significant differences (P > 0.05).Conclusion:
Administering lidocaine in combination with gamma globulin through airway causes significant decrease the rate and reduce the amount of local absorption of lidocaine in cats.Key words
Full text:
1
Index:
LILACS
Main subject:
Gamma-Globulins
/
Epinephrine
/
Adrenergic beta-Agonists
/
Respiratory Tract Absorption
/
Anesthetics, Local
/
Lidocaine
Type of study:
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2017
Type:
Article