The effects of subcutaneous injection of nicotine on osseointegration of machined and anodized implants in rabbits
Acta cir. bras
;
33(1): 31-39, Jan. 2018. graf
Article
in English
| LILACS
| ID: biblio-886250
ABSTRACT
Abstract Purpose:
To evaluate the influence of subcutaneous injection nicotine in osseointegration process on different implant surfaces.Methods:
Twenty-two male rabbits were distributed into two groups according to the subcutaneous injections (1) nicotine 3 mg/day/kg and (2) 0.9 % NaCI 3 mL/day/kg, three times a day; subgroups were then designated-machined and anodized implants were placed in the right and left tibia bones, respectively. The animals were submitted euthanasia after periods of eight weeks to determine nicotine and cotinine levels, alkaline phosphatase and biomechanical analysis.Results:
The plasmatic levels of nicotine and cotinine were 0.5 ± 0.28 ng/mL and 9.5 ± 6.51 ng/mL, respectively. The alkaline phosphatase analyses in blood levels in control group were observed 40.8 ± 11.88 UI/L and 40.75 ± 12.46 UI/L, for the surfaces machined and anodized, respectively. In the test group was observed levels 37.9 ± 4.84 UI/L, for both implant surfaces. No significant differences were observed between control and test groups and between the implant surfaces regarding alkaline phosphatase blood levels. For biomechanics, no significant differences were observed in control group between the machined (25±8.46 Ncm) or anodized (31.2 ± 6.76 Ncm) implants. However, the treatment with nicotine induced higher torque than control in both machined (38.3 ± 13.52 Ncm) and anodized (35.5 ± 14.17 Ncm) implants, with p = 0.0024 and p = 0.0121, respectively.Conclusion:
Subcutaneous injection of nicotine following implant insertion didn't have effect on osseointegration, independently from the implant surface.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Dental Implants
/
Osseointegration
/
Bone-Implant Interface
/
Nicotine
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de Passo Fundo/BR
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