Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits
Acta cir. bras
;
33(1): 22-30, Jan. 2018. tab
Article
in English
| LILACS
| ID: biblio-886251
ABSTRACT
Abstract Purpose:
To investigate the influence of dexmedetomidine on myocardial ischemia-reperfusion injury (IRI) in rabbits.Methods:
Twenty-four New Zealand white rabbits were randomly divided into two equal-sized groups IRI group (group IR) and dexmedetomidine group (group D). Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular diastolic pressure (LVDP), +dp/dtmax, -dp/dtmax, and t-dp/dtmax were recorded and calculated at the following time points before (T0) and after (T1) dexmedetomidine infusion, after 30-min ischemia (T2), and after 120-min reperfusion (T3). The levels of plasma endothelin 1 (ET-1), thromboxane A2 (TXA2), and platelet activating factor (PAF); area of myocardial infarction (MI); and no-reflow area were evaluated.Results:
SBP, DBP, LVSP, LVEDP, LVDP, and +dp/dtmax at T3 were higher in group D than in group IR (P<0.05). The average no-reflow area in group IR was significantly smaller than that in group D (14±3% vs. 38±5%, P=0.0116). The ET-1, TXA2, and PAF levels at T2 and T3 were higher than those at T0 in both groups (P<0.05).Conclusion:
Dexmedetomidine could reduce the magnitude of ischemic myocardial no-reflow area and protect the myocardium with ischemia-reperfusion injury.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Myocardial Reperfusion Injury
/
Dexmedetomidine
/
Adrenergic alpha-2 Receptor Agonists
Type of study:
Evaluation studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Hebei Medical University/CN
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