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Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema
Silva, Samanta Sarmento da; Peterson, Guilherme Eckert; Amantéa, Sérgio Luis; Miorelli, Patrícia; Ulbrich, Jane Maria; Roesch, Eliane; Sanches, Paulo Roberto; Fraga, Jose Carlos.
  • Silva, Samanta Sarmento da; Universidade Federal do Rio Grande do Sul. School of Medicine. Postgraduate Program in Surgical Sciences. Porto Alegre. BR
  • Peterson, Guilherme Eckert; Universidade Federal do Rio Grande do Sul. School of Medicine. Postgraduate Program in Surgical Sciences. Porto Alegre. BR
  • Amantéa, Sérgio Luis; Universidade Federal do Rio Grande do Sul. School of Medicine. Postgraduate Program in Surgical Sciences. Porto Alegre. BR
  • Miorelli, Patrícia; Universidade Federal do Rio Grande do Sul. School of Medicine. Postgraduate Program in Surgical Sciences. Porto Alegre. BR
  • Ulbrich, Jane Maria; Universidade Federal do Rio Grande do Sul. School of Medicine. Postgraduate Program in Surgical Sciences. Porto Alegre. BR
  • Roesch, Eliane; Universidade Federal do Rio Grande do Sul. School of Medicine. Postgraduate Program in Surgical Sciences. Porto Alegre. BR
  • Sanches, Paulo Roberto; Universidade Federal do Rio Grande do Sul. School of Medicine. Postgraduate Program in Surgical Sciences. Porto Alegre. BR
  • Fraga, Jose Carlos; Universidade Federal do Rio Grande do Sul. School of Medicine. Postgraduate Program in Surgical Sciences. Porto Alegre. BR
Acta cir. bras ; 33(2): 156-162, Feb. 2018. tab, graf
Article in English | LILACS | ID: biblio-886258
ABSTRACT
Abstract

Purpose:

To evaluate the concentration of transforming growth factor beta 1 (TGFB1) levels in a rat pleural effusion obtained by inoculation of intrapleural bacteria or turpentine through thoracentesis.

Methods:

Thirty-Nine Wistar rats were divided into three groups Staphylococcus aureus (SA, n = 17); Streptococcus pneumoniae (SP, n = 12); and turpentine (control, n = 10). Pleural fluid was collected through ultrasound-guided thoracentesis 12 h, 24 h, and 36 h after instillation of bacteria or turpentine. Levels of TGFB1 were measured in pleural fluid.

Results:

At 12 h, mean TGFB1concentrations were 5.3450 pg/mL in the SA group, 5.3449 pg/mL in the SP group, and 5.3450 pg/mL in controls. At 24 h, they were 4.6700 pg/mL in the SA group, 4.6700 pg/mL in the SP group, and 4.6700 pg/mL in controls. At 36 h, they were 4.6699 pg/mL in the SA group and in control. No difference was observed among the groups in mean TGFB1concentration (p = 0.12); however, a significant intragroup reduction in mean TGFB1 was observed between 12 and 24 h (p < 0.01).

Conclusion:

The transforming growth factor beta 1 concentrations were not useful as a diagnostic tool or an early marker of infected pleural effusion.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pleural Effusion / Empyema, Pleural / Transforming Growth Factor beta1 Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pleural Effusion / Empyema, Pleural / Transforming Growth Factor beta1 Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Sul/BR