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Effect of powdered shells treatment of the snail Megalobulimus lopesi on wounds of diabetic rats
Andrade, Paulo Henrique Muleta; Portugal, Luciane Canderolo; Rondon, Eric Schmidt; Kadri, Monica Cristina Toffoli; Matos, Maria de Fátima Cepa.
  • Andrade, Paulo Henrique Muleta; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development of the Central West Region. Campo Grande. BR
  • Portugal, Luciane Canderolo; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development of the Central West Region. Campo Grande. BR
  • Rondon, Eric Schmidt; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development of the Central West Region. Campo Grande. BR
  • Kadri, Monica Cristina Toffoli; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development of the Central West Region. Campo Grande. BR
  • Matos, Maria de Fátima Cepa; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development of the Central West Region. Campo Grande. BR
Acta cir. bras ; 33(2): 185-196, Feb. 2018. graf
Article in English | LILACS | ID: biblio-886265
ABSTRACT
Abstract

Purpose:

To analyzed the healing effect of the powdered shell of the Megalobulimus lopesi snail on wounds of diabetic rats, since in non-diabetic rats the powdered shell presented healing potential.

Methods:

Seventy-two Wistar rats (Rattus norvegicus albinus) were divided into three groups Control group (GC.diab), no therapeutic intervention on the wound; Vehicle's Control group, topical via, in diabetic rats (GCvt.diab) Powder Shell Group (PC) applied topically (GPCvt.diab) Experimental group was administered topically shortly after wound dressing and once a day during the experimental period (3, 7, 14 and 21 days) the composition containing the powdered shell of the snail. The following variables related to the healing potential were analyzed macroscopic one, where the capacity of reduction of the wound area was evaluated; histological analysis in HE, angiogenic activity, morphometric analysis (re-epithelization), leukocyte inflammatory infiltrate; leukocyte count and also differentiation in peripheral blood.

Results:

The topical application in wounds of diabetic rats presented healing activity, accelerating wound closure, stimulating angiogenesis and being pro-inflammatory in the early and anti-inflammatory stages in the final times of the healing process.

Conclusion:

The topical administration of the powdered shell on wounds of diabetic patients becomes a therapeutic option of low cost, with ease in the administration and access as well.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Snails / Tissue Extracts / Wound Healing / Diabetes Mellitus, Experimental / Animal Shells / Anti-Inflammatory Agents Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Mato Grosso do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Snails / Tissue Extracts / Wound Healing / Diabetes Mellitus, Experimental / Animal Shells / Anti-Inflammatory Agents Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Mato Grosso do Sul/BR