The role of oxymatrine in regulating TGF-ß1 in rats with hepatic fibrosis
Acta cir. bras
;
33(3): 207-215, Mar. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-886274
ABSTRACT
Abstract Purpose:
To investigate whether oxymatrine (OMT) prevents hepatic fibrosis in rats by regulating liver transforming growth factor β1 (TGF-β1) level.Methods:
Hepatic fibrosis was induced in rats by thioacetamide (TAA). Blood was collected at the end of week 12 to determine the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutathione (GSH). Changes in liver tissue were observed after hematoxylin-eosin (HE) staining.Results:
Fibrosis was confirmed by Masson's collagen staining. Liver TGF-β1 level was determined by ELISA. OMT significantly reduced serum ALT and AST but increased GSH levels in rats with hepatic fibrosis. Moreover, it significantly improved liver histology in rats with TAA-induced hepatic fibrosis. It significantly decreased liver TGF-β1 level compared to that in the untreated group. It also significantly reduced collagen deposition in rats.Conclusion:
Oxymatrine is effective in protecting rats from thioacetamide-induced hepatic fibrosis by regulating TGF-β1 expression.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Quinolizines
/
Protective Agents
/
Alkaloids
/
Transforming Growth Factor beta1
/
Liver Cirrhosis, Experimental
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Ningxia Medical University/CN
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