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The effect of metyrosine on oxidative gastric damage induced by ischemia/reperfusion in rats. Biochemical and histopathological evaluation
Çimen, Orhan; Çimen, Ferda Keskin; Gülapoğlu, Mine; Bilgin, Aslı Özbek; Çekiç, Arif Burak; Eken, Hüseyin; Süleyman, Zeynep; Bilgin, Yasin; Altuner, Durdu.
  • Çimen, Orhan; Erzincan University. Faculty of Medicine. Department of General Surgery. TR
  • Çimen, Ferda Keskin; Erzincan University. Faculty of Medicine. Department of General Surgery. TR
  • Gülapoğlu, Mine; Erzincan University. Faculty of Medicine. Department of General Surgery. TR
  • Bilgin, Aslı Özbek; Erzincan University. Faculty of Medicine. Department of General Surgery. TR
  • Çekiç, Arif Burak; Erzincan University. Faculty of Medicine. Department of General Surgery. TR
  • Eken, Hüseyin; Erzincan University. Faculty of Medicine. Department of General Surgery. TR
  • Süleyman, Zeynep; Erzincan University. Faculty of Medicine. Department of General Surgery. TR
  • Bilgin, Yasin; Erzincan University. Faculty of Medicine. Department of General Surgery. TR
  • Altuner, Durdu; Erzincan University. Faculty of Medicine. Department of General Surgery. TR
Acta cir. bras ; 33(3): 259-267, Mar. 2018. graf
Article in English | LILACS | ID: biblio-886275
ABSTRACT
Abstract

Purpose:

To investigate the effect of metyrosine against I/R induced gastric damage in rats.

Methods:

Eighteen albino Wistar male rats were divided into groups; gastric I/R (GIR), 50 mg/kg metyrosine+gastric I/R (MGIR), and sham (SG) groups. 50 mg/kg metyrosine was given to the MGIR group, and distilled water was given to the GIR and SG groups by the oral gavage. After 30 minutes, 25 mg/kg thiopental sodium was injected intraperitoneally. Ischemia was achieved for 1 hour by clamping the celiac artery of the MGIR and GIR groups, then reperfusion was achieved for 3 hours. After that, animals were killed with 50 mg/kg thiopental. Biochemical and histopathological examinations performed on the gastric tissues.

Results:

Metyrosine decreased the MDA and MPO and the increased the tGSH and SOD. In addition, it reduced inflammation by suppressing the decrease of COX-1 and the increase of COX-2. Histopathologically, metyrosine decreased symptoms caused by I/R such as mucosal necrosis, hemorrhage, edema, PMNL infiltration, and dilated congested blood vessels.

Conclusions:

Metyrosine prevented the I/R induced oxidative stress in the gastric tissue. Metyrosine may be beneficial for gastric I/R injury.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Oxidative Stress / Alpha-Methyltyrosine / Enzyme Inhibitors / Gastric Mucosa Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Turkey Institution/Affiliation country: Erzincan University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Oxidative Stress / Alpha-Methyltyrosine / Enzyme Inhibitors / Gastric Mucosa Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Turkey Institution/Affiliation country: Erzincan University/TR