Vascular endothelial growth factor association with angiopoietin 1 promotes improvement in ventricular function after ischemic cardiomyopathy induced in mini pigs
Acta cir. bras
;
33(4): 386-395, Apr. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-886279
ABSTRACT
Abstract Purpose:
To investigate the safety and clinical, hemodynamic and tissue improvement ability in mini pigs undergoing cell and gene therapy for the treatment of acute myocardial infarction.Methods:
Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarction by occlusion of the diagonal branch of the paraconal coronary. They were divided into 4 groups one control group and 3 treatment groups (cell therapy and gene cell therapy). Echocardiography reviews were performed on three occasions and histopathological analysis was performed after 4 weeks. Analysis of variance (ANOVA), Tukey and Wilcoxon tests, were performed.Results:
Association of vascular endothelial growth factor (VEGF) with angiopoietin1 (Ang1) presented satisfactory results in the improvement of ventricular function following ischemic cardiomyopathy in mini pigs when compared to the results of the other treated groups.Conclusion:
The therapy with VEGF and the combination of VEGF with Ang1, promoted recovered function of the myocardium, characterized by reduced akinetic area and induction of neovascularization.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Genetic Therapy
/
Ventricular Function
/
Angiopoietin-1
/
Vascular Endothelial Growth Factor A
/
Cell- and Tissue-Based Therapy
/
Myocardial Infarction
Type of study:
Evaluation studies
/
Prognostic study
/
Risk factors
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual do Norte Fluminense Darcy Ribeiro/BR
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