Effect of cilostazol in experimental model of degloving injuries in rat limbs
Acta cir. bras
; 33(4): 296-305, Apr. 2018. tab, graf
Article
in En
| LILACS
| ID: biblio-886282
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the effect of the cilostazol on the evolution of partially avulsed flaps, using experimental model of cutaneous degloving in rat limbs.Methods:
A controlled and randomized experimental study was carried out in which the blood flow and the percentage of flap necrosis were evaluated. We compared the study group, which received cilostazol, and the control group, which received enteral saline solution in the postoperative period. The blood flow in the flap was evaluated through Laser Doppler flowmetry, and a planimetry using the IMAGE J® software was employed for the calculation of the area of necrosis.Results:
Enteral administration of cilostazol was associated with a higher mean blood flow in all regions of the flap, with a statistically significant difference in the proximal and middle regions (p<0.001) and a lower percentage of necrotic area in the flap (p<0.001).Conclusion:
Postoperative enteral administration of cilostazol increased blood flow and decreased the total area of necrosis of avulsed cutaneous flaps of rat limbs.Key words
Full text:
1
Index:
LILACS
Main subject:
Tetrazoles
/
Disease Models, Animal
/
Phosphodiesterase 3 Inhibitors
/
Degloving Injuries
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article