Impact of dexmedetomidine on hemodynamics in rabbits
Acta cir. bras
;
33(4): 314-323, Apr. 2018. tab
Article
in English
| LILACS
| ID: biblio-886285
ABSTRACT
Abstract Purpose:
To evaluate the effects of single intravenous administration of Dexmedetomidine (DEX) on hemodynamics in rabbits.Methods:
A total of 32 New Zealand white rabbits were randomly divided into the control group (Group C), Group D1 (2.75 μg/kg), Group D2 (5.5 μg/kg), and Group D3 (8.25 μg/kg) to compare systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), central venous pressure (CVP), left ventricular systolic pressure (LVSP), left ventricular end-stage diastolic pressure (LVEDP), left ventricular developmental pressure (LVDP), +dp/dtmax, -dp/dtmax, and t-dp/dtmax at different time points.Results:
The levels of SBP, DBP, HR, LVSP, and LVEDP in Group D1, D2, and D3 were lower than that of Group C from T1 to T5 (P<0.05), but there was no significant difference at T6 and T7 (P>0.05). Compared with T0, the levels of SBP, DBP, HR, LVSP, LVEDP, and left arterial pressure (LAP) from T1 to T7 were decreased (P<0.05), but there was no significant difference in the other indexes (P>0.05).Conclusion:
Dexmedetomidine can decrease blood pressure and heart rate in rabbits in a dose-dependent manner, but there is no effect on the myocardial systolic and diastolic function.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Dexmedetomidine
/
Hemodynamics
/
Hypnotics and Sedatives
Type of study:
Evaluation studies
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Second Hospital of Hebei Medical University/CN
Similar
MEDLINE
...
LILACS
LIS