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Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs
GÓMEZ-CANSINO, ROCIO; GUZMÁN-GUTIÉRREZ, SILVIA LAURA; CAMPOS-LARA, MARÍA GUADALUPE; ESPITIA-PINZÓN, CLARA INES; REYES-CHILPA, RICARDO.
  • GÓMEZ-CANSINO, ROCIO; Universidad Nacional Autónoma de México. Departamento de Productos Naturales. Instituto de Química. México. MX
  • GUZMÁN-GUTIÉRREZ, SILVIA LAURA; Universidad Nacional Autónoma de México. Departamento de Productos Naturales. Instituto de Química. México. MX
  • CAMPOS-LARA, MARÍA GUADALUPE; Universidad Nacional Autónoma de México. Departamento de Productos Naturales. Instituto de Química. México. MX
  • ESPITIA-PINZÓN, CLARA INES; Universidad Nacional Autónoma de México. Departamento de Productos Naturales. Instituto de Química. México. MX
  • REYES-CHILPA, RICARDO; Universidad Nacional Autónoma de México. Departamento de Productos Naturales. Instituto de Química. México. MX
An. acad. bras. ciênc ; 89(1): 31-43, Jan,-Mar. 2017. graf
Article in English | LILACS | ID: biblio-886638
ABSTRACT
ABSTRACT In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activity in vitro. Among these, the most potent is Aristolochia brevipes (MIC= 12.5 µg/mL), followed by Aristolochia taliscana, Citrus sinensis, Chrysactinia mexicana, Persea americana, and Olea europaea (MIC<64 µg/mL). Other potent extracts (inhibition > 95%, 50 µg/mL) include Amphipterygium adstringens, Larrea divaricata, and Phoradendron robinsoni. Several active compounds have been identified, the most potent are Licarin A (isolated from A. taliscana), and 9-amino-9-methoxy-3,4-dihydro-2H-benzo[h]-chromen-2-one (transformation product of 9-methoxytariacuripyrone isolated from Aristolochia brevipes), both with MIC= 3.125 µg/mL, that is 8-fold less potent than the reference drug Rifampicin (MIC= 0.5 µg/mL). Any of the compounds or extracts here reviewed has been studied in clinical trials or with animal models; however, these should be accomplished since several are active against strains resistant to common drugs.
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Full text: Available Index: LILACS (Americas) Main subject: Plants, Medicinal / Plant Extracts / Antitubercular Agents Type of study: Prognostic study Country/Region as subject: Mexico Language: English Journal: An. acad. bras. ciênc Journal subject: Science Year: 2017 Type: Article Affiliation country: Mexico Institution/Affiliation country: Universidad Nacional Autónoma de México/MX

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Full text: Available Index: LILACS (Americas) Main subject: Plants, Medicinal / Plant Extracts / Antitubercular Agents Type of study: Prognostic study Country/Region as subject: Mexico Language: English Journal: An. acad. bras. ciênc Journal subject: Science Year: 2017 Type: Article Affiliation country: Mexico Institution/Affiliation country: Universidad Nacional Autónoma de México/MX