Immune System Dysfunction in the Elderly
An. acad. bras. ciênc
;
89(1): 285-299, Jan,-Mar. 2017. graf
Article
in English
| LILACS
| ID: biblio-886643
ABSTRACT
ABSTRACT Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this function is unclear. In this article the function of the immune system during aging is explored.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Immunosenescence
/
Immune System
/
Immune System Diseases
Limits:
Aged
/
Aged80
/
Humans
Language:
English
Journal:
An. acad. bras. ciênc
Journal subject:
Science
Year:
2017
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Talca/CL
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