Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
An. acad. bras. ciênc
;
89(3): 1369-1379, July-Sept. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-886755
ABSTRACT
ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
Full text:
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Index:
LILACS (Americas)
Main subject:
Triterpenes
/
Lamiaceae
/
Pentacyclic Triterpenes
/
Fabaceae
/
Antineoplastic Agents
Limits:
Humans
Language:
English
Journal:
An. acad. bras. ciênc
Journal subject:
Science
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal da Bahia/BR
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