Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol
An. acad. bras. ciênc
;
89(3): 1555-1564, July-Sept. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-886762
ABSTRACT
ABSTRACT Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antibacterial activity test with extracts of branches and heartwood and bark of roots from Maytenus gonoclada were conducted. Moreover, due the frequency of isolation of lupeol from Maytenus genus the antiviral activity against Dengue virus and cytotoxicity of lupeol and its complex with β-cyclodextrins were also tested. The results indicated the bioactivity of ethyl acetate extract from branches and ethanol extract from heartwood of roots of M. gonoclada against diarrheagenic bacteria. The lupeol showed potent activity against Dengue virus and low cytotoxicity in LLC-MK2 cells, but its complex with β-cyclodextrin was inactive. Considering the importance of novel and selective antiviral drug candidates the results seem to be promising.
Full text:
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Index:
LILACS (Americas)
Main subject:
Antiviral Agents
/
Plant Extracts
/
Maytenus
/
Dengue Virus
/
Pentacyclic Triterpenes
/
Anti-Bacterial Agents
/
Antidiarrheals
Language:
English
Journal:
An. acad. bras. ciênc
Journal subject:
Science
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade do Estado de Minas Gerais/BR
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