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Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
LUCINDA, LEDA M F; AARESTRUP, BEATRIZ J V; REBOREDO, MAYCON M; PAINS, THAIS D A; CHAVES, RAPHAEL Z; REIS, JOÃO E P; LOUZADA, MÁRIO J Q; GUERRA, MARTHA O.
  • LUCINDA, LEDA M F; Universidade Federal de Juiz de Fora. Centro de Biologia da Reprodução. Juiz de Fora. BR
  • AARESTRUP, BEATRIZ J V; Universidade Federal de Juiz de Fora. Centro de Biologia da Reprodução. Juiz de Fora. BR
  • REBOREDO, MAYCON M; Universidade Federal de Juiz de Fora. Centro de Biologia da Reprodução. Juiz de Fora. BR
  • PAINS, THAIS D A; Universidade Federal de Juiz de Fora. Centro de Biologia da Reprodução. Juiz de Fora. BR
  • CHAVES, RAPHAEL Z; Universidade Federal de Juiz de Fora. Centro de Biologia da Reprodução. Juiz de Fora. BR
  • REIS, JOÃO E P; Universidade Federal de Juiz de Fora. Centro de Biologia da Reprodução. Juiz de Fora. BR
  • LOUZADA, MÁRIO J Q; Universidade Federal de Juiz de Fora. Centro de Biologia da Reprodução. Juiz de Fora. BR
  • GUERRA, MARTHA O; Universidade Federal de Juiz de Fora. Centro de Biologia da Reprodução. Juiz de Fora. BR
An. acad. bras. ciênc ; 89(4): 2833-2841, Oct.-Dec. 2017. graf
Article in English | LILACS | ID: biblio-886830
ABSTRACT
ABSTRACT Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis's (Student's t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett'T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry.
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Full text: Available Index: LILACS (Americas) Main subject: Osteoporosis / Plant Extracts / Bone Density Limits: Animals Language: English Journal: An. acad. bras. ciênc Journal subject: Science Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Juiz de Fora/BR

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Full text: Available Index: LILACS (Americas) Main subject: Osteoporosis / Plant Extracts / Bone Density Limits: Animals Language: English Journal: An. acad. bras. ciênc Journal subject: Science Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Juiz de Fora/BR