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Antiedematogenic activity of the indole derivative N-salicyloyltryptamine in animal models
SOUSA-NETO, BENEDITO P; GOMES, BRUNO S; CUNHA, FRANCISCO V M; ARCANJO, DANIEL D R; GUTIERREZ, STANLEY J C; SOUZA, MARIA F V; ALMEIDA, FERNANDA R C; OLIVEIRA, FRANCISCO A.
  • SOUSA-NETO, BENEDITO P; Universidade Federal do Piauí. Núcleo de Pesquisas em Plantas Medicinais. Teresina. BR
  • GOMES, BRUNO S; Universidade Federal do Piauí. Núcleo de Pesquisas em Plantas Medicinais. Teresina. BR
  • CUNHA, FRANCISCO V M; Universidade Federal do Piauí. Núcleo de Pesquisas em Plantas Medicinais. Teresina. BR
  • ARCANJO, DANIEL D R; Universidade Federal do Piauí. Núcleo de Pesquisas em Plantas Medicinais. Teresina. BR
  • GUTIERREZ, STANLEY J C; Universidade Federal do Piauí. Núcleo de Pesquisas em Plantas Medicinais. Teresina. BR
  • SOUZA, MARIA F V; Universidade Federal do Piauí. Núcleo de Pesquisas em Plantas Medicinais. Teresina. BR
  • ALMEIDA, FERNANDA R C; Universidade Federal do Piauí. Núcleo de Pesquisas em Plantas Medicinais. Teresina. BR
  • OLIVEIRA, FRANCISCO A; Universidade Federal do Piauí. Núcleo de Pesquisas em Plantas Medicinais. Teresina. BR
An. acad. bras. ciênc ; 90(1): 185-194, Mar. 2018. tab, graf
Article in English | LILACS | ID: biblio-886919
ABSTRACT
ABSTRACT The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. The potential NST-induced antiedematogenic activity was evaluated by carrageenan-induced paw edema in rats, as well as by dextran-, compound 48/80-, histamine-, serotonin-, capsaicine-, and prostaglandin E2-induced paw edema in mice. The effect of NST on compound 48/80-induced ex vivo mast cell degranulation on mice mesenteric bed was investigated. No death or alteration of behavioral parameters was observed after administration of NST (2000 mg/kg, i.p.) during the observation time of 14 days. The NST (100 and 200 mg/kg, i.p.) inhibited the carrageenan-induced edema from the 1st to the 5th hour (**p<0.01; ***p<0.001). The edematogenic activity induced by dextran, compound 48/80, histamine, serotonin, capsaicin, and prostaglandin E2 was inhibited by NST (100 mg/kg, i.p.) throughout the observation period (**p<0.01; ***p<0.001). The pretreatment with NST (50, 100 or 200 mg/kg, i.p) attenuates the compound 48/80-induced mast cell degranulation (**p<0.01; ***p<0.001). Thus, the inhibition of both mast cell degranulation and release of endogenous mediators are probably involved in the NST-induced antiedematogenic effect.
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Full text: Available Index: LILACS (Americas) Main subject: Tryptamines / Salicylates / Edema / Anti-Inflammatory Agents Type of study: Prognostic study Limits: Animals Language: English Journal: An. acad. bras. ciênc Journal subject: Science Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Piauí/BR

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Full text: Available Index: LILACS (Americas) Main subject: Tryptamines / Salicylates / Edema / Anti-Inflammatory Agents Type of study: Prognostic study Limits: Animals Language: English Journal: An. acad. bras. ciênc Journal subject: Science Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Piauí/BR