Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo
An. bras. dermatol
;
92(3): 312-318, May-June 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-886974
ABSTRACT
Abstract Background:
Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases.Objectives:
To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo.Methods:
Case series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects. The maximum follow-up period for some patients was 24 months.Results:
Of the 20 patients who underwent 24 procedures, 25% showed an excellent rate of repigmentation, 50% good repigmentation, 15% regular, and 10% poor response. The best results were observed in face and neck lesions, while the worst in extremity lesions (88% and 33% of satisfactory responses, respectively). Patients with segmental vitiligo had a better response (84%) compared to non-segmental ones (63%). As side effects were observed hyperpigmentation of the treated area and the appearance of Koebner phenomenon in the donor area. Studylimitations:
Some limitations of the study included the small number of patients, a subjective evaluation, and the lack of long-term follow-up on the results.CONCLUSION:
Noncultured epidermal cell suspension transplantation is efficient and well tolerated for stable vitiligo treatment, especially for segmental vitiligo on the face and neck.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vitiligo
/
Keratinocytes
/
Melanocytes
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Fumec/BR
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