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Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study
Belli, Asli Akin; Altun, Ilknur; Altun, Ibrahim.
  • Belli, Asli Akin; Mugla Sitki Kocman University. Training and Research Hospital. Department of Dermatology. Muğla. TR
  • Altun, Ilknur; Mugla Sitki Kocman University. Training and Research Hospital. Department of Dermatology. Muğla. TR
  • Altun, Ibrahim; Mugla Sitki Kocman University. Training and Research Hospital. Department of Dermatology. Muğla. TR
An. bras. dermatol ; 92(6): 820-825, Nov.-Dec. 2017. tab
Article in English | LILACS | ID: biblio-887113
ABSTRACT
Abstract

Background:

Rosacea is a chronic facial skin disease associated with excessive inflammatory response to various triggers. Although some studies have supported the increased risk of cardiovascular diseases in rosacea, it has not been completely accepted.

Objective:

We aimed to investigate epicardial fat thickness and carotid intima-media thickness as cardiovascular risk predictors in rosacea patients.

Methods:

We conducted a cross-sectional study including 40 rosacea patients and 40 controls. Demographic data, epicardial fat thickness, carotid intima-media thickness, lipid parameters, biochemical parameters, presence of insulin resistance, and presence of metabolic syndrome of the participants were recorded.

Results:

Forty rosacea patients (31 female and 9 male) and 40 controls (30 female and 10 male) were enrolled in the study. Rosacea patients had significantly higher epicardial fat thickness and carotid intima-media thickness volumes than controls (P<0.001). In the multivariate logistic regression analysis, epicardial fat thickness was independently related to presence of rosacea (P<0.001, OR=13.31). In the multiple linear regression analysis, the epicardial fat thickness was independently associated with rosacea (β= 0.47, P<0.001), carotid intima-media thickness (β= 0.36, P<0.001), and systolic blood pressure (β=0.19, P=0.015) and the carotid intima-media thickness was independently associated with epicardial fat thickness (β= 0.6, P<0.001). The epicardial fat thickness levels were correlated with carotid intima-media thickness (r=0.63, P<0.001), LDL (r=0.23, P=0.037), systolic blood pressure (r=0.45, P<0.001), and diastolic blood pressure levels (r=0.37, P=0.001). The carotid intima-media thickness levels were correlated with epicardial fat thickness (r=0.63, P<0.001), systolic blood pressure (r=0.04, P<0.001), and diastolic blood pressure levels (r=0.27, P=0.016). Study

limitations:

The small number of participants.

Conclusions:

Examination and follow-up of rosacea patients for cardiovascular diseases may be recommended practices.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pericardium / Cardiovascular Diseases / Adipose Tissue / Rosacea / Carotid Intima-Media Thickness Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: Mugla Sitki Kocman University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Pericardium / Cardiovascular Diseases / Adipose Tissue / Rosacea / Carotid Intima-Media Thickness Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: Mugla Sitki Kocman University/TR