How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?
An. bras. dermatol
;
92(6): 826-829, Nov.-Dec. 2017. tab
Article
in English
| LILACS
| ID: biblio-887130
ABSTRACT
Abstract Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Psoriasis
/
Intercellular Adhesion Molecule-1
/
Capillary Leak Syndrome
/
Vascular Endothelial Growth Factor A
Limits:
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade do Estado do Rio de Janeiro/BR
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