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Blocking or enhancing effects of some basic emollients in UVA penetration
Akarsu, Sevgi; Fetil, Emel; Ozbagcivan, Ozlem; Gunes, Ali Tahsin.
  • Akarsu, Sevgi; Dokuz Eylul University. Faculty of Medicine. Department of Dermatology. Izmir. TR
  • Fetil, Emel; Dokuz Eylul University. Faculty of Medicine. Department of Dermatology. Izmir. TR
  • Ozbagcivan, Ozlem; Dokuz Eylul University. Faculty of Medicine. Department of Dermatology. Izmir. TR
  • Gunes, Ali Tahsin; Dokuz Eylul University. Faculty of Medicine. Department of Dermatology. Izmir. TR
An. bras. dermatol ; 93(2): 238-241, Mar.-Apr. 2018. tab, graf
Article in English | LILACS | ID: biblio-887175
ABSTRACT
Abstract

Background:

Topical agents used in combination with phototherapy or photochemotherapy may have both blocking or enhancing effects in ultraviolet rays.

Objective:

In this in vivo study, the effects of topical petrolatum, basis cream, glycerine, and olive oil on the transmission of ultraviolet A radiation were investigated.

Methods:

A test was performed to determine the minimal phototoxic dose on 29 volunteers with only psoralen plus ultraviolet A (PUVA) and then the same test was repeated with white petrolatum, basis cream, glycerine, olive oil, and sunscreen (0.3cc/25cm2). The effects of each agent on the minimal phototoxic dose were determined after 72 h.

Results:

When compared to pure PUVA, there was a statistically significant increase in the mean minimal phototoxic dose values by the application of white petrolatum (P = 0.011), but there was no significant increase or decrease in the mean minimal phototoxic dose values after the application of basis cream (P = 0.326), glycerine (P = 0.611) or olive oil (P = 0.799). Study

limitations:

Low number of patients

Conclusion:

The application of white petrolatum, which has a blocking effect, and also of basis cream immediately before PUVA therapy should not be recommended. Although we specify that glycerine and maybe olive oil can be used before photochemotherapy, there is a need for further research in larger series.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Petrolatum / Photochemotherapy / PUVA Therapy / Skin Diseases / Ultraviolet Rays / Photosensitizing Agents / Emollients Type of study: Controlled clinical trial / Evaluation studies Limits: Humans Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2018 Type: Article Affiliation country: Turkey Institution/Affiliation country: Dokuz Eylul University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Petrolatum / Photochemotherapy / PUVA Therapy / Skin Diseases / Ultraviolet Rays / Photosensitizing Agents / Emollients Type of study: Controlled clinical trial / Evaluation studies Limits: Humans Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2018 Type: Article Affiliation country: Turkey Institution/Affiliation country: Dokuz Eylul University/TR