Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver Transplantation
Ann. hepatol
;
16(2): 230-235, Mar.-Apr. 2017. tab
Article
in English
| LILACS
| ID: biblio-887227
ABSTRACT
ABSTRACT Background. Chronic renal failure (CRF) is a significant cause of morbidity and mortality in post-liver transplantation (LT) recipients. The risk factors associated with the development of renal dysfunction are not clearly elucidated. Objectives. To examine the risk factors in the development of CRF in these patients. Material and methods. Retrospective case-cohort of liver transplant patients without baseline kidney dysfunction who developed chronic renal failure during their follow-up. Results. Of 370 patients, 254 met the inclusion criteria. 30% (76) of these patients had CRF of which 57% (43) were male. Age, estimated glomerular filtration rate (eGFR) at discharge, and HCV infection were found to be risk factors for CRF post-LT. The odds ratio of developing CRF was 1.4 (0.6-3.3) in males with HCV, 1.6 (0.7-3.9) in females without HCV and 4.4 (1.5-13.2) among females with HCV when compared to men without HCV. Conclusions. In this cohort of LT receipients of a major Canadian city, age, eGFR, and HCV infection were risk factors for CRF. Female gender and HCV increased this odds by a factor of more than 4.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Liver Transplantation
/
Hepatitis C
/
Kidney Failure, Chronic
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
North America
Language:
English
Journal:
Ann. hepatol
Journal subject:
Gastroenterology
Year:
2017
Type:
Article
Affiliation country:
Canada
Institution/Affiliation country:
University of British Columbia/CA
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