Your browser doesn't support javascript.
loading
The Impact of Early Dermatologic Events in the Survival of Patients with Hepatocellular Carcinoma Treated with Sorafenib
Branco, Fernanda; Alencar, Regiane S. M; Volt, Fernanda; Sartori, Giovana; Dode, Andressa; Kikuchi, Luciana; Tani, Claudia M; Chagas, Aline L; Pfiffer, Tulio; Hoff, Paulo; Carrilho, Flair J; Mattos, Angelo Alves de.
  • Branco, Fernanda; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Alencar, Regiane S. M; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Volt, Fernanda; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Sartori, Giovana; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Dode, Andressa; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Kikuchi, Luciana; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Tani, Claudia M; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Chagas, Aline L; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Pfiffer, Tulio; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Hoff, Paulo; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Carrilho, Flair J; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
  • Mattos, Angelo Alves de; Federal University of Health Sciences of Porto Alegre. Department of Hepatology. BR
Ann. hepatol ; 16(2): 263-268, Mar.-Apr. 2017. tab, graf
Article in English | LILACS | ID: biblio-887231
ABSTRACT
ABSTRACT Background and Aims. The presence of dermatologic reaction as an adverse event to sorafenib treatment in patients with unresectable hepatocellular carcinoma has been indicated as a prognostic factor for survival in a recent prospective analysis. To date, this is the only clinical predictor of treatment response, which can be evaluated earlier in the treatment and, therefore, contribute to a better and more individualized patient management. Material and methods. This retrospective study included 127 patients treated with sorafenib under real-life practice conditions in two hepatology reference centers in Brazil. Demographic data, disease/medical history and time of sorafenib administration as well as adverse events related to the medication were recorded in a database. Results. Cirrhosis was present in 94% of patients, 85.6% were Child-Pugh A, 80.3%BCLC-C, 81% had vascular invasion and/or extrahepatic spread and 95% had a performance status 0 to 1.The median duration of treatment was 10.1 months (range 0.1-47 months).The most common adverse event within the first 60 days of treatment were diarrhea (62.2%) and dermatological reaction (42%).The median overall survival for the cohort was 20 months, and it was higher for patients who developed dermatological reactions within the first 60 days compared to those who did not present this adverse event. Conclusion. This retrospective analysis showed the use of sorafenib in patients selected according to BCLC staging, and it is the first external validation of early dermatologic adverse events as a predictor of overall survival in patients with advanced hepatocellular carcinoma.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Phenylurea Compounds / Niacinamide / Drug Eruptions / Carcinoma, Hepatocellular / Liver Neoplasms / Antineoplastic Agents Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study Limits: Humans Language: English Journal: Ann. hepatol Journal subject: Gastroenterology Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Health Sciences of Porto Alegre/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Phenylurea Compounds / Niacinamide / Drug Eruptions / Carcinoma, Hepatocellular / Liver Neoplasms / Antineoplastic Agents Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study Limits: Humans Language: English Journal: Ann. hepatol Journal subject: Gastroenterology Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Health Sciences of Porto Alegre/BR