Transient Elastography vs Aspartate Aminotransferase to Platelet Ratio Index in Hepatitis C: A Meta-Analysis
Ann. hepatol
;
16(3): 349-357, May.-Jun. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-887246
ABSTRACT
ABSTRACT Background and rationale. Many different non-invasive methods have been studied with the purpose of staging liver fibrosis. The objective of this study was verifying if transient elastography is superior to aspartate aminotransferase to platelet ratio index for staging fibrosis in patients with chronic hepatitis C. Material and methods. A systematic review with meta-analysis of studies which evaluated both non-invasive tests and used biopsy as the reference standard was performed. A random-effects model was used, anticipating heterogeneity among studies. Diagnostic odds ratio was the main effect measure, and summary receiver operating characteristic curves were created. A sensitivity analysis was planned, in which the meta-analysis would be repeated excluding each study at a time. Results. Eight studies were included in the meta-analysis. Regarding the prediction of significant fibrosis, transient elastography and aspartate aminotransferase to platelet ratio index had diagnostic odds ratios of 11.70 (95% confidence interval = 7.13-19.21) and 8.56 (95% confidence interval = 4.90-14.94) respectively. Concerning the prediction of cirrhosis, transient elastography and aspartate aminotransferase to platelet ratio index had diagnostic odds ratios of 66.49 (95% confidence interval = 23.71- 186.48) and 7.47 (95% confidence interval = 4.88-11.43) respectively. Conclusion. In conclusion, there was no evidence of significant superiority of transient elastography over aspartate aminotransferase to platelet ratio index regarding the prediction of significant fibrosis, but the former proved to be better than the latter concerning prediction of cirrhosis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Aspartate Aminotransferases
/
Hepatitis C
/
Clinical Enzyme Tests
/
Elasticity Imaging Techniques
/
Liver Cirrhosis
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Ann. hepatol
Journal subject:
Gastroenterology
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Pontifical Catholic University of Rio Grande do Sul/BR
Similar
MEDLINE
...
LILACS
LIS