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The role of moderate-to-vigorous physical activity in mediating the relationship between central adiposity and immunometabolic profile in postmenopausal women
Diniz, Tiego A; Rossi, Fabricio E; Silveira, Loreana S; Neves, Lucas Melo; Fortaleza, Ana Claudia de Souza; Christofaro, Diego G D; Lira, Fabio S; Freitas-Junior, Ismael F.
  • Diniz, Tiego A; Universidade de São Paulo. São Paulo. BR
  • Rossi, Fabricio E; Universidade de São Paulo. São Paulo. BR
  • Silveira, Loreana S; Universidade de São Paulo. São Paulo. BR
  • Neves, Lucas Melo; Universidade de São Paulo. São Paulo. BR
  • Fortaleza, Ana Claudia de Souza; Universidade de São Paulo. São Paulo. BR
  • Christofaro, Diego G D; Universidade de São Paulo. São Paulo. BR
  • Lira, Fabio S; Universidade de São Paulo. São Paulo. BR
  • Freitas-Junior, Ismael F; Universidade de São Paulo. São Paulo. BR
Arch. endocrinol. metab. (Online) ; 61(4): 354-360, July-Aug. 2017. tab, graf
Article in English | LILACS | ID: biblio-887572
ABSTRACT
ABSTRACT Objectives To analyze the role of moderate-to-vigorous physical activity (MVPA) in mediating the relationship between central adiposity and immune and metabolic profile in postmenopausal women. Materials and methods Cross-sectional study comprising 49 postmenopausal women (aged 59.26 ± 8.32 years) without regular physical exercise practice. Body composition was measured by dual-energy X-ray absorptiometry. Fasting blood samples were collected for assessment of nonesterified fatty acids, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), adiponectin, insulin and estimation of insulin resistance (HOMA-IR). Physical activity level was assessed with an accelerometer (Actigraph GTX3x) and reported as a percentage of time spent in sedentary behavior and MVPA. All analyses were performed using the software SPSS 17.0, with a significance level set at 5%. Results Sedentary women had a positive relationship between trunk fat and IL-6 (rho = 0.471; p = 0.020), and trunk fat and HOMA-IR (rho = 0.418; p = 0.042). Adiponectin and fat mass (%) were only positively correlated in physically active women (rho = 0.441; p = 0.027). Physically active women with normal trunk fat values presented a 14.7% lower chance of having increased HOMA-IR levels (β [95%CI] = 0.147 [0.027; 0.811]). Conclusions The practice of sufficient levels of MVPA was a protective factor against immunometabolic disorders in postmenopausal women.
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Full text: Available Index: LILACS (Americas) Main subject: Exercise / Interleukin-6 / Postmenopause / Obesity, Abdominal Type of study: Observational study / Prevalence study / Risk factors Limits: Aged / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Exercise / Interleukin-6 / Postmenopause / Obesity, Abdominal Type of study: Observational study / Prevalence study / Risk factors Limits: Aged / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR