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New insights into the effects of irisin levels in HIV-infected subjects: correlation with adiposity, fat-free mass, and strength parameters
Trombeta, Joice Cristina dos Santos; Prestes, Jonato; Nascimento, Dahan da Cunha; Tibana, Ramires Alsamir; Pereira, Guilherme Borges; Lima, Thiago da Rosa; Fraga, Géssica Alves; Vieira-Junior, Roberto Carlos; Voltarelli, Fabrício Azevedo.
  • Trombeta, Joice Cristina dos Santos; Universidade Estadual de Campinas. Campinas. BR
  • Prestes, Jonato; Universidade Estadual de Campinas. Campinas. BR
  • Nascimento, Dahan da Cunha; Universidade Estadual de Campinas. Campinas. BR
  • Tibana, Ramires Alsamir; Universidade Estadual de Campinas. Campinas. BR
  • Pereira, Guilherme Borges; Universidade Estadual de Campinas. Campinas. BR
  • Lima, Thiago da Rosa; Universidade Estadual de Campinas. Campinas. BR
  • Fraga, Géssica Alves; Universidade Estadual de Campinas. Campinas. BR
  • Vieira-Junior, Roberto Carlos; Universidade Estadual de Campinas. Campinas. BR
  • Voltarelli, Fabrício Azevedo; Universidade Estadual de Campinas. Campinas. BR
Arch. endocrinol. metab. (Online) ; 61(4): 382-390, July-Aug. 2017. tab, graf
Article in English | LILACS | ID: biblio-887578
ABSTRACT
ABSTRACT Objective Patients infected with the human immunodeficiency virus (HIV) have an increased risk of metabolic disorders and alterations on irisin levels. Therefore, the purpose of the current investigation was to quantify the circulating irisin concentration in HIV-infected subjects under highly active antiretroviral therapy and to determine possible correlations between irisin levels with fat mass, fat-free mass, body mass index (BMI), and muscle strength. Subjects and methods Cross-sectional study of 10 men (36.7 ± 11.3 years) and 10 women (42.5 ± 10.3 years) infected with HIV, recruited from the Specialized Service Center in the State Center of Reference for High and Medium Complexity. Blood samples were collected to determine plasma irisin levels, glucose, HDL, total cholesterol, triglycerides, and LDL. Body composition (fat mass, fat-free mass) and anthropometrics (body mass index; BMI) were measured by bioelectrical impedance. Muscle strength was assessed using a mechanic hand dynamometer and one maximum repetition tests. Results Irisin levels correlated positively with fat mass (r = 0.67; p = 0.001) and BMI (r = 0.48; p = 0.036). In contrast, there was an inverse correlation between irisin levels and fat-free mass (r = -0.41; p = 0.008) and five strength parameters right hand grip (r = -0.46; p = 0.044); left hand grip (r = -0.50; p = 0.027), relative hand grip (r = -0.79; p = 0.001), bench press (r = -0.58; p = 0.009), leg press (r = -0.40; p = 0.085), and biceps curl (r = -0.059; p = 0.009). Conclusion Irisin levels correlated positively with body fat and negatively with fat-free mass and strength parameters in HIV-infected patients. Female patients infected with HIV receiving highly active antiretroviral therapy have higher levels of irisin compared with men in a similar circumstance.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: HIV Infections / Adipose Tissue / Fibronectins Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: HIV Infections / Adipose Tissue / Fibronectins Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR