Circulating omentin-1 might be associated with metabolic health status in different phenotypes of body size
Arch. endocrinol. metab. (Online)
; 61(6): 567-574, Dec. 2017. tab
Article
in En
| LILACS
| ID: biblio-887608
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Objective Adipokines are mediators of body composition and are involved in obesity complications. This study aimed to assess the association of circulating omentin-1, vaspin, and RBP-4 with body composition indices and metabolic health status (MHS) in different phenotypes of body size. Subjects and methods A total of 350 subjects were included in the current cross-sectional study. Body composition was measured using a body composition analyzer, and serum concentrations of omentin-1, vaspin, and RBP-4 were assessed by ELISA kits. Results Circulating omentin-1 was significantly (OR = 1.81, 95% CI 1.00-1.91, P = 0.01) and marginally (OR = 1.63, 95%CI 1.00-1.75, P = 0.06) associated with MHS in the overweight and obese subjects, respectively. But no association was seen between omentin-1 and MHS in normal-weight subjects. Serum levels of vaspin and RBP-4 were not correlated with MHS. Furthermore, a significant positive correlation was observed between circulating omentin-1 and body mass index (BMI) as well as fat percentage (P = 0.02) in the MHS group. Serum vaspin concentrations were not related to body composition components in both groups. In addition, in the MHS group, circulating RBP-4 was positively correlated with fat percentage and fat mass (FM) (p < 0.0001) and was negatively correlated with fat-free mass (FFM) and total body water (TBW) (p < 0.0001). In contrast, in the metabolically unhealthy group, RBP-4 was negatively correlated with fat percentage, FM, and BMI (p < 0.0001) and was positively correlated with FFM and TBW (p < 0.0001). Conclusions This study showed that circulating levels of omentin-1 are useful predictors of metabolic health status in overweight and obese people.
Key words
Full text:
1
Index:
LILACS
Main subject:
Body Composition
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Serpins
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Cytokines
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Body Size
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Retinol-Binding Proteins, Plasma
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Lectins
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Obesity
Type of study:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limits:
Adult
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Female
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Humans
Language:
En
Journal:
Arch. endocrinol. metab. (Online)
Journal subject:
ENDOCRINOLOGIA
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METABOLISMO
Year:
2017
Type:
Article