Your browser doesn't support javascript.
loading
Associação de interleucina-10-1082A/polimorfismo G (rs1800896) com suscetibilidade a câncer gástrico: meta-análise de 6. 101 casos e 8. 557 controles / Association of interleukin-10 -1082 a/g (rs1800896) polymorphism with susceptibility to gastric cancer: meta-analysis of 6, 101 cases and 8, 557 controls
Namazi, Abolfazl; Forat-Yazdi, Mohammad; Jafari,, Mohammadali; Farahnak, Soudabeh; Nasiri, Rezvan; Foroughi, Elnaz; Abolbaghaei, Seyed Mojtaba; Neamatzadeh, Hossein.
  • Namazi, Abolfazl; Shahid Sadoughi University of Medical Sciences. Department of Internal Medicine. Yazd. IR
  • Forat-Yazdi, Mohammad; Shahid Sadoughi University of Medical Sciences. Department of Internal Medicine. Yazd. IR
  • Jafari,, Mohammadali; Shahid Sadoughi University of Medical Sciences. Department of Internal Medicine. Yazd. IR
  • Farahnak, Soudabeh; Shahid Sadoughi University of Medical Sciences. Department of Internal Medicine. Yazd. IR
  • Nasiri, Rezvan; Shahid Sadoughi University of Medical Sciences. Department of Internal Medicine. Yazd. IR
  • Foroughi, Elnaz; Shahid Sadoughi University of Medical Sciences. Department of Internal Medicine. Yazd. IR
  • Abolbaghaei, Seyed Mojtaba; Shahid Sadoughi University of Medical Sciences. Department of Internal Medicine. Yazd. IR
  • Neamatzadeh, Hossein; Shahid Sadoughi University of Medical Sciences. Department of Internal Medicine. Yazd. IR
Arq. gastroenterol ; 55(1): 33-40, Apr.-Mar. 2018. tab, graf
Article in English | LILACS | ID: biblio-888237
ABSTRACT
ABSTRACT

BACKGROUND:

The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent.

OBJECTIVE:

To clarify the association, we conducted a meta-analysis to investigate the associations IL-10 -1082 A/G polymorphism with gastric cancer.

METHODS:

Eligible articles were identified by searching databases including PubMed, Web of Science, and Google Scholar up to August 03, 2017. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association.

RESULTS:

A total of 30 case-control studies with 6,101 cases and 8,557 controls were included in this meta-analysis. Overall, a significant association between IL-10 -1082 A/G polymorphism and gastric cancer risk was observed under the allele model (G vs A OR=1.305, 95% CI=1.076-1.584; P=0.007), heterozygote model and (GA vs AA OR=1.252, 95% CI=1.252-1.054; P=0.011) and dominant model (GG+GA vs AA OR=1.264, 95% CI=1.053-1.516; P=0.012). In the subgroup analysis by ethnicity, increased gastric cancer risk were found in Asians under the allele model (G vs A OR=1.520, 95% CI=1.172-1.973; P=0.002), homozygote model (GG+GA vs AA OR=1.571, 95% CI=1.023-2.414; P= 0.039), heterozygote model (GA vs AA OR=1.465, 95% CI=1.192-1.801; P≤0.001) and dominant model (GG+GA vs AA OR=1.448, 95% CI=1.152-1.821; P=0.002), but not among Caucasian and Latinos populations.

CONCLUSION:

These results suggested that the IL-10 -1082 A/G (rs1800896) polymorphism might contribute to the gastric cancer susceptibility, especially among Asians.
RESUMO
RESUMO

CONTEXTO:

O promotor-1082 A/polimorfismo G (rs1800896) do gene da interleucina-10 (IL-10) é amplamente relatado e considerado por ter um papel significativo no risco de câncer gástrico, porém os resultados são inconsistentes.

OBJETIVO:

Para esclarecer melhor esta associação, realizou-se uma meta-análise para investigar as associações de IL-10-1082 A/polimorfismo G com câncer gástrico.

MÉTODOS:

Artigos elegíveis foram identificados através de pesquisa de bases de dados PubMed, Web of Science e Google Scholar até 3 de agosto de 2017. Razões de possibilidades (OR) com intervalo de confiança de 95% correspondente (CIs) foram usados para avaliar a associação.

RESULTADOS:

Um total de 30 estudos de caso-controle, 6.101 casos e com 8.557 controles foram incluídos nesta meta-análise. Em geral, uma associação significativa entre IL-10-1082 A/G polimorfismo e risco de câncer gástrico foi observada sob o modelo de alelo (G vs A OR=1.305, 95% CI=1.076-1.584; P=0.007), no modelo heterozigoto (GA vs AA OR=1.252, 95% CI=1.252-1.054; P=0.011) e modelo dominante (GG+GA vs AA OR=1.264, 95% CI=1.053-1.516; P=0.012). Na análise de subgrupo pela etnia, foi encontrado risco aumentado de câncer gástrico em asiáticos sob o modelo de alelo (G vs A OR=1.520, 95% CI=1.172-1.973; P=0.002), modelo heterozigoto (GG+GA vs AA OR=1.571, 95% CI=1.023-2.414; P= 0.039), e modelo dominante (GG+GA vs AA OR=1.448, 95% CI=1.152-1.821; P=0.002), mas não entre a população caucasiana e latina.

CONCLUSÃO:

Estes resultados sugeriram que a IL-10-1082 A/polimorfismo G (rs1800896) pode contribuir para a suscetibilidade de câncer gástrico, especialmente entre os asiáticos.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Stomach Neoplasms / Interleukin-10 Type of study: Etiology study / Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Humans Language: English Journal: Arq. gastroenterol Journal subject: Gastroenterology Year: 2018 Type: Article Affiliation country: Iran Institution/Affiliation country: Shahid Sadoughi University of Medical Sciences/IR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Stomach Neoplasms / Interleukin-10 Type of study: Etiology study / Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Humans Language: English Journal: Arq. gastroenterol Journal subject: Gastroenterology Year: 2018 Type: Article Affiliation country: Iran Institution/Affiliation country: Shahid Sadoughi University of Medical Sciences/IR