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Epidemiological and clinical factors impact on the benefit of riluzole in the survival rates of patients with ALS / Impacto de fatores epidemiológicos e clínicos sobre o benefício do riluzol nas taxas de sobrevida de pacientes com ELA
Fávero, Francis Meire; Voos, Mariana Callil; Castro, Isac de; Caromano, Fátima Aparecida; Oliveira, Acary Souza Bulle.
  • Fávero, Francis Meire; Universidade Federal de São Paulo. Departamento de Neurologia e Neurocirurgia. São Paulo. BR
  • Voos, Mariana Callil; Universidade Federal de São Paulo. Departamento de Neurologia e Neurocirurgia. São Paulo. BR
  • Castro, Isac de; Universidade Federal de São Paulo. Departamento de Neurologia e Neurocirurgia. São Paulo. BR
  • Caromano, Fátima Aparecida; Universidade Federal de São Paulo. Departamento de Neurologia e Neurocirurgia. São Paulo. BR
  • Oliveira, Acary Souza Bulle; Universidade Federal de São Paulo. Departamento de Neurologia e Neurocirurgia. São Paulo. BR
Arq. neuropsiquiatr ; 75(8): 515-522, Aug. 2017. tab, graf
Article in English | LILACS | ID: biblio-888317
ABSTRACT
ABSTRACT Objective To investigate the impact of epidemiological and clinical factors on the benefit of riluzole in patients with amyotrophic lateral sclerosis (ALS). Methods The survival rate of 578 patients with ALS (1999-2011) was analyzed by descriptive statistics and Kaplan-Meier curves. Considering the median of the sample survival time (19 months), patients were divided in two groups below (B19) and above the median (A19). Kaplan-Meier curves compared the survival rates of patients treated with riluzole and with patients who did not take the medication. Results Riluzole increased the survival rates of patients with lower limb onset who were diagnosed after the first appointment in B19. Patients with bulbar onset and diagnosed on the first, or after the first appointment showed higher survival rates in A19. Males lived longer than females in both groups. Conclusion Epidemiological and clinical factors influenced the benefit of riluzole in the survival rates of patients with ALS.
RESUMO
RESUMO Objetivo Investigar o impacto de fatores epidemiológicos e clínicos sobre o benefício do riluzole em pacientes com esclerose lateral amiotrófica (ELA). Métodos A sobrevida de 578 pacientes com ELA (1999-2011) foi analisada por estatística descritiva e curvas de Kaplan-Meier. Considerando a mediana do tempo de sobrevida (19 meses), a amostra foi subdividida em dois grupos sobrevida abaixo (B19) e acima de 19 meses (A19). As curvas de Kaplan-Meier compararam a sobrevida de pacientes tratados com riluzole e com pacientes que não receberam tratamento. Resultados O riluzole aumentou a sobrevida de pacientes com início nos membros inferiores e diagnosticados após a primeira consulta no grupo B19. Pacientes com início bulbar e diagnosticados na primeira/ após a primeira consulta apresentaram maior sobrevida em A19. Os homens apresentaram sobrevida maior do que as mulheres. Conclusão Foram encontradas diferenças epidemiológicas e clínicas no benefício do riluzole em pacientes com ELA.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Neuroprotective Agents / Riluzole / Amyotrophic Lateral Sclerosis Type of study: Diagnostic study / Observational study / Risk factors Limits: Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Neuroprotective Agents / Riluzole / Amyotrophic Lateral Sclerosis Type of study: Diagnostic study / Observational study / Risk factors Limits: Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR