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Cell Derived Microparticles in Gingival Crevicular Fluid from Periodontitis Patients with Type 2 Diabetes
Figueredo, Carlos Marcelo; Lira Junior, Ronaldo; Sete, Manuela Rubim; Fischer, Ricardo Guimarães.
  • Figueredo, Carlos Marcelo; Universidade do Estado do Rio de Janeiro. Department of Periodontology, School of Dentistry. Rio de Janeiro. BR
  • Lira Junior, Ronaldo; Universidade do Estado do Rio de Janeiro. Department of Periodontology, School of Dentistry. Rio de Janeiro. BR
  • Sete, Manuela Rubim; Universidade do Estado do Rio de Janeiro. Department of Periodontology, School of Dentistry. Rio de Janeiro. BR
  • Fischer, Ricardo Guimarães; Universidade do Estado do Rio de Janeiro. Department of Periodontology, School of Dentistry. Rio de Janeiro. BR
Braz. dent. j ; 28(6): 675-678, Nov.-Dec. 2017. graf
Article in English | LILACS | ID: biblio-888702
ABSTRACT
Abstract Cell-derived microparticles (MPs) have been described as vital contributors to the inflammatory process. However, its role in the periodontal disease pathogenesis remains unclear. Therefore, we aimed to detect the presence neutrophil (CD66b+) and platelet (CD41b+) derived microparticles in gingival crevicular fluid from individuals having periodontitis aggravated by type 2 diabetes. Twelve patients (56.2 ±7.2 yrs) with severe form of chronic periodontitis aggravated by type 2 diabetes were included. Clinical and metabolic data were gathered. Gingival crevicular fluid was collected using filter strips from deep and shallow sites. MPs were detected by flow cytometry according to their size (< 1 µm) and the expression of surface markers (CD66b for neutrophil-derived MPs and CD41b for platelet-derived MPs). All samples were positive for the antibodies. Median levels of CD66b+ MPs and CD41b+ MPs were, respectively, 3,677.0 (2,553.2 - 9,059.8) MP/µL and 520.7 (432.9 - 766.1) MP/µL in deep sites. In shallow sites, the corresponding values were 2,644.9 (1,451.5 - 3,858.9) MP/µL and 371.2 (287.2 - 692.7) MP/µL. There was no significant difference between deep and shallow sites (p>0.05). In conclusion, this study reported the presence of neutrophil and platelet derived microparticles in gingival crevicular fluid from individuals having severe periodontitis and type 2 diabetes.
RESUMO
Resumo As micropartículas derivadas de células (MPs) têm sido descritas como contribuintes vitais para o processo inflamatório. No entanto, seu papel na patogênese da doença periodontal permanece obscuro. Por isso, nosso objetivo foi detectar a presença de micropartículas derivadas de neutrófilos (CD66b +) e plaquetas (CD41b +) no fluido gengival de indivíduos com periodontite e diabetes tipo 2. Doze pacientes (56,2 ± 7,2 anos) com periodontite crônica severa e diabetes tipo 2 foram incluídos no estudo. Foram coletados dados clínicos e metabólicos. O fluido gengival foi coletado usando tiras de filtro de papel em sítios rasos e profundos. As MPs foram detectadas por citometria de fluxo de acordo com o seu tamanho (<1 μm) e pela expressão de marcadores de superfície (CD66b para MPs derivadas de neutrófilos e CD41b para MPs derivadas de plaquetas). Todas as amostras foram positivas para os anticorpos. Os níveis médios de CD66b + MPs e CD41b + MPs foram, respectivamente, 3.677.0 (2,553.2 - 9,059.8) MP/μL e 520.7 (432.9 - 766.1) MP/μL nos sítios profundos. Nos sítios rasos, os valores correspondentes foram 2,644.9 (1,451.5 - 3,858.9) MP/μL e 371.2 (287.2 - 692.7) MP/μL. Não houve diferença significativa entre os sítios rasos e profundos (p>0.05). Concluindo, o presente estudo reportou a presença de micropartículas derivadas de neutrófilos e plaquetas no fluido gengival de pacientes com periodontite e com diabetes tipo 2 .
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Full text: Available Index: LILACS (Americas) Main subject: Periodontitis / Gingival Crevicular Fluid / Diabetes Mellitus, Type 2 / Cell-Derived Microparticles Limits: Female / Humans / Male Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade do Estado do Rio de Janeiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Periodontitis / Gingival Crevicular Fluid / Diabetes Mellitus, Type 2 / Cell-Derived Microparticles Limits: Female / Humans / Male Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade do Estado do Rio de Janeiro/BR