Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients
Braz. j. infect. dis
;
21(6): 606-612, Nov.-Dec. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-888923
ABSTRACT
ABSTRACT Introduction:
The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy. Materials andmethods:
A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients' serums were tested for (1-3)-β-D-Glugan, galactomannan, and lactate dehydrogenase. The association among the variables was analyzed by univariate and multivariate regression analysis.Results:
60 patients were included in the study. The patients were classified in three groups Pneumocystis jirovecii pneumonia (19 patients), community-acquired pneumonia (18 patients), and other infections (23 patients). The overall mortality was 13.3%. The time since diagnosis of HIV infection was shorter in the pneumocystosis group (4.94 years; p = 0.001) than for the other two groups of patients. The multivariate analysis showed that higher (1-3)-β-D-Glucan level (mean 241 pg/mL) and lactate dehydrogenase (mean 762 U/L) were associated with the diagnosis of pneumocystosis. Pneumocystosis was the aids-defining illness in 11 out of 16 newly diagnosed HIV-infected patients.Conclusion:
In the era of antiretroviral therapy, PJP was still the most prevalent pulmonary infection and (1-3)-β-D-Glucan and lactate dehydrogenase may be suitable markers to help diagnosing pneumocystosis in our HIV population.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
AIDS-Related Opportunistic Infections
/
Beta-Glucans
/
L-Lactate Dehydrogenase
/
Lung Diseases, Fungal
/
Mannans
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de Campinas/BR
Similar
MEDLINE
...
LILACS
LIS