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Meta-analysis of the association between PADI4 -92C/G polymorphism and rheumatoid arthritis in the Chinese population
Guo, ZY; Zhang, JX; Wu, M; Mei, YF; Lin, XJ; Bu, C; Xie, Y; Wang, J.
  • Guo, ZY; Zhejiang University. Department of Orthopedic Surgery. Hangzhou. CN
  • Zhang, JX; Zhejiang University. Department of Orthopedic Surgery. Hangzhou. CN
  • Wu, M; Zhejiang University. Department of Orthopedic Surgery. Hangzhou. CN
  • Mei, YF; Zhejiang University. Department of Orthopedic Surgery. Hangzhou. CN
  • Lin, XJ; Zhejiang University. Department of Orthopedic Surgery. Hangzhou. CN
  • Bu, C; Zhejiang University. Department of Orthopedic Surgery. Hangzhou. CN
  • Xie, Y; Zhejiang University. Department of Orthopedic Surgery. Hangzhou. CN
  • Wang, J; Zhejiang University. Department of Orthopedic Surgery. Hangzhou. CN
Braz. j. med. biol. res ; 50(10): e6115, 2017. tab, graf
Article in English | LILACS | ID: biblio-888931
ABSTRACT
Many studies have evaluated the correlation between peptidylarginine deiminase 4 (PADI4) -92C/G polymorphism and rheumatoid arthritis (RA), but the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between PADI4 -92C/G polymorphism and RA. Eligible studies published before May 2016 were identified in PubMed and Chinese databases. The strengths of these associations were assessed by pooled odds ratios (OR) and 95% confidence interval (CI). Eight studies documenting a total of 1351 RA cases and 1585 controls were included in this meta-analysis. In the overall analysis, a significant association between the PADI4 -92C/G polymorphism and RA was found in the Chinese population (G vs C OR=1.32, 95%CI=1.02-1.71; GG+CG vs CC OR=1.75, 95%CI=1.20-2.53). The subgroup analyses stratified by geographic area(s) and source of controls revealed significant results in South China, in hospital-based studies and population-based studies. In summary, this meta-analysis suggested that PADI4 -92C/G polymorphism may be associated with the RA incidence in the Chinese population, especially for South China. Further studies conducted on other ethnic groups are required for definite conclusions.
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Full text: Available Index: LILACS (Americas) Main subject: Arthritis, Rheumatoid / Polymorphism, Single Nucleotide / Protein-Arginine Deiminases Type of study: Etiology study / Prognostic study / Risk factors / Systematic reviews Limits: Humans Country/Region as subject: Asia Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2017 Type: Article Affiliation country: China Institution/Affiliation country: Zhejiang University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Arthritis, Rheumatoid / Polymorphism, Single Nucleotide / Protein-Arginine Deiminases Type of study: Etiology study / Prognostic study / Risk factors / Systematic reviews Limits: Humans Country/Region as subject: Asia Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2017 Type: Article Affiliation country: China Institution/Affiliation country: Zhejiang University/CN