Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
Braz. j. med. biol. res
;
50(11): e6353, 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-888951
ABSTRACT
This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Adjuvants, Pharmaceutic
/
Curcumin
/
Enzyme Inhibitors
/
Intestinal Absorption
/
Intestine, Small
Type of study:
Evaluation studies
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2017
Type:
Article
/
Project document
Affiliation country:
China
Institution/Affiliation country:
Chongqing Academy of Chinese Materia Medica/CN
Similar
MEDLINE
...
LILACS
LIS