Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
Braz. j. med. biol. res
;
50(11): e6455, 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-888957
ABSTRACT
Series of novel coumarin derivatives [I (a-d) and II (a-d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their cytotoxicity, which was tested against SK-LU-1, SPC-A-1 and 95D human lung cancer cell lines, using the MTT assay. The results of this study showed that compounds Ic, Id, IIc, and IId exhibited an efficient percentage of inhibition of cell proliferation.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Coumarins
/
Lung Neoplasms
/
Antineoplastic Agents
Type of study:
Evaluation studies
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2017
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Chongqing Cancer Institute/CN
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