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Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility
Wu, BW; Zhu, J; Shi, HM; Jin, B; Wen, ZC.
  • Wu, BW; Fudan University. Huashan Hospital. Department of Cardiology,. Shanghai. CN
  • Zhu, J; Fudan University. Huashan Hospital. Department of Cardiology,. Shanghai. CN
  • Shi, HM; Fudan University. Huashan Hospital. Department of Cardiology,. Shanghai. CN
  • Jin, B; Fudan University. Huashan Hospital. Department of Cardiology,. Shanghai. CN
  • Wen, ZC; Fudan University. Huashan Hospital. Department of Cardiology,. Shanghai. CN
Braz. j. med. biol. res ; 50(9): e6306, 2017. tab, graf
Article in English | LILACS | ID: biblio-888996
ABSTRACT
Published data on the association between Toll-like receptor 4 (TLR4) Asp299Gly polymorphism and coronary heart disease (CHD) susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. English-language studies were identified by searching PubMed and Embase databases (up to November 2016). All epidemiological studies were regarding Caucasians because no TLR4 Asp/Gly and Gly/Gly genotypes have been detected in Asians. A total of 20 case-control studies involving 14,416 cases and 10,764 controls were included in the meta-analysis. Overall, no significant associations were found between TLR4 Asp299Gly polymorphism and CHD susceptibility in the dominant model (OR=0.89; 95%CI=0.74 to 1.06; P=0.20) pooled in the meta-analysis. In the subgroup analysis by CHD, non-significant associations were found in cases compared to controls. When stratified by control source, no significantly decreased risk was found in the additive model or dominant model. The present meta-analysis suggests that the TLR4 Asp299Gly polymorphism was not associated with decreased CHD risk in Caucasians.
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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Coronary Disease / Genetic Predisposition to Disease / Toll-Like Receptor 4 Type of study: Observational study / Risk factors / Systematic reviews Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2017 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Fudan University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Coronary Disease / Genetic Predisposition to Disease / Toll-Like Receptor 4 Type of study: Observational study / Risk factors / Systematic reviews Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2017 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Fudan University/CN