Synthesis, crystal structure, and anti-breast cancer activity of a novel metal-porphyrinic complex [YK(TCPP)(OH)2·(solvents)x]

Liu, J-C; Gu, J-J; Zhang, Y-S

Liu, J-C; Gu, J-J; Zhang, Y-S.

Liu, J-C; Huaihe Hospital of Henan University. Department of Radiotherapy. Kaifeng. CN
Gu, J-J; Huaihe Hospital of Henan University. Department of Radiotherapy. Kaifeng. CN
Zhang, Y-S; Huaihe Hospital of Henan University. Department of Radiotherapy. Kaifeng. CN

Braz. j. med. biol. res ; 51(1): e6858, 2018. tab, graf

Article in English | LILACS | ID: biblio-889001

ABSTRACT

ABSTRACT

A novel heterometallic metal-porphyrinic framework (MPFs) built from Y and K ions as nods and meso-tetra(4-carboxyphenyl)porphyrin as linkers has been successfully synthesized and characterized. The single crystal X-ray diffraction indicated that this complex 1 exhibited a bilayered architecture of the porphyrins, which is seldom seen in MPFs. In addition, in vitro anticancer activity of complex 1 on three human breast cancer cells (BT474, SKBr-3 and ZR-75-30) was further determined.

Subject(s)

Humans; Porphyrins/chemistry; Breast Neoplasms/drug therapy; Metal-Organic Frameworks/pharmacology; Metal-Organic Frameworks/chemistry; Antineoplastic Agents/pharmacology; Antineoplastic Agents/chemistry; Reference Values; Tetrazolium Salts; Reproducibility of Results; Crystallography, X-Ray; Cell Line, Tumor; Coordination Complexes/pharmacology; Coordination Complexes/chemistry; Formazans

Breast cancer cell; Heterometallic; Single crystal

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Full text: Available Index: LILACS (Americas) Main subject: Porphyrins / Breast Neoplasms / Metal-Organic Frameworks / Antineoplastic Agents Type of study: Evaluation studies Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Huaihe Hospital of Henan University/CN

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