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Correlation between serum 25-hydroxyvitamin D levels and carotid intima-media thickness in a Brazilian population descended from African slaves
Monteiro Júnior, FC; Mandarino, NR; Santos, EM; Santos, AM; Salgado, JV; Brito, DJA; Salgado, BJL; Lages, JS; Castelo Branco, G; Salgado Filho, N.
  • Monteiro Júnior, FC; Universidade Federal do Maranhão. Serviço de Cardiologia. São Luís. BR
  • Mandarino, NR; Universidade Federal do Maranhão. Serviço de Cardiologia. São Luís. BR
  • Santos, EM; Universidade Federal do Maranhão. Serviço de Cardiologia. São Luís. BR
  • Santos, AM; Universidade Federal do Maranhão. Serviço de Cardiologia. São Luís. BR
  • Salgado, JV; Universidade Federal do Maranhão. Serviço de Cardiologia. São Luís. BR
  • Brito, DJA; Universidade Federal do Maranhão. Serviço de Cardiologia. São Luís. BR
  • Salgado, BJL; Universidade Federal do Maranhão. Serviço de Cardiologia. São Luís. BR
  • Lages, JS; Universidade Federal do Maranhão. Serviço de Cardiologia. São Luís. BR
  • Castelo Branco, G; Universidade Federal do Maranhão. Serviço de Cardiologia. São Luís. BR
  • Salgado Filho, N; Universidade Federal do Maranhão. Serviço de Cardiologia. São Luís. BR
Braz. j. med. biol. res ; 51(4): e7185, 2018. tab
Article in English | LILACS | ID: biblio-889065
ABSTRACT
Hypovitaminosis D has been identified as a possible new cardiovascular risk factor. However, the results of studies correlating serum vitamin D levels with markers of subclinical atherosclerosis have been conflicting. The aim of this study was to correlate serum levels of 25-hydroxyvitamin D [25(OH)D] with carotid intima-media thickness (C-IMT) and conventional cardiovascular risk factors in Afro-descendants. A cross-sectional analysis was performed on a sample of 382 individuals from a cohort of descendants of African slaves, inhabitants of "Quilombola" communities, with a mean age of 57.79 ±15.3 years, 54.5% of whom were women. Socio-demographic and clinical data were collected and biochemical tests were performed, including serum levels of 25(OH)D by electrochemiluminescence and urinary albumin excretion, evaluated by the albumin/creatinine ratio (ACR) in a spot urine sample. All participants underwent high-resolution ultrasonography for C-IMT measurement. Hypovitaminosis D was defined as serum 25(OH)D levels <30 ng/mL. The mean serum 25(OH)D levels were 50.4±13.5 ng/mL, with a low prevalence of hypovitaminosis D (4.86%). By simple linear correlation, a significant inverse association between 25(OH)D levels and C-IMT (r=-0.174, P=0.001) was observed. However, after multiple linear regression analysis, the significance of the association between serum levels of 25(OH)D and C-IMT measurement was lost (β=-0.039, P=0.318) and only male gender, age, smoking, systolic blood pressure, glucose and low density lipoprotein (LDL)-cholesterol remained significantly associated with C-IMT. Levels of 25(OH)D were independently and positively associated with HDL-cholesterol and inversely associated with age and ACR. In conclusion, no independent association between 25(OH)D levels and C-IMT was observed in this population. On the other hand, there was an inverse association with albuminuria, a marker of endothelial lesion.
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Full text: Available Index: LILACS (Americas) Main subject: Vitamin D / Vitamin D Deficiency / Black People / Atherosclerosis / Carotid Intima-Media Thickness Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Maranhão/BR

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Full text: Available Index: LILACS (Americas) Main subject: Vitamin D / Vitamin D Deficiency / Black People / Atherosclerosis / Carotid Intima-Media Thickness Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Maranhão/BR