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Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model
Callejas, GH; Figueira, RL; Gonçalves, FLL; Volpe, FAP; Zuardi, AW; Crippa, JA; Hallak, JE; Sbragia, L.
  • Callejas, GH; Universidade de São Paulo. Departamento de Cirurgia e Anatomia Faculdade de Medicina de Ribeirão Preto. Laboratório de Cirurgia Experimental Fetal e Neonatal "Michael Harrison" Divisão de Cirurgia Pediátrica. Ribeirão Preto. BR
  • Figueira, RL; Universidade de São Paulo. Departamento de Cirurgia e Anatomia Faculdade de Medicina de Ribeirão Preto. Laboratório de Cirurgia Experimental Fetal e Neonatal "Michael Harrison" Divisão de Cirurgia Pediátrica. Ribeirão Preto. BR
  • Gonçalves, FLL; Universidade de São Paulo. Departamento de Cirurgia e Anatomia Faculdade de Medicina de Ribeirão Preto. Laboratório de Cirurgia Experimental Fetal e Neonatal "Michael Harrison" Divisão de Cirurgia Pediátrica. Ribeirão Preto. BR
  • Volpe, FAP; Universidade de São Paulo. Departamento de Cirurgia e Anatomia Faculdade de Medicina de Ribeirão Preto. Laboratório de Cirurgia Experimental Fetal e Neonatal "Michael Harrison" Divisão de Cirurgia Pediátrica. Ribeirão Preto. BR
  • Zuardi, AW; Universidade de São Paulo. Departamento de Cirurgia e Anatomia Faculdade de Medicina de Ribeirão Preto. Laboratório de Cirurgia Experimental Fetal e Neonatal "Michael Harrison" Divisão de Cirurgia Pediátrica. Ribeirão Preto. BR
  • Crippa, JA; Universidade de São Paulo. Departamento de Cirurgia e Anatomia Faculdade de Medicina de Ribeirão Preto. Laboratório de Cirurgia Experimental Fetal e Neonatal "Michael Harrison" Divisão de Cirurgia Pediátrica. Ribeirão Preto. BR
  • Hallak, JE; Universidade de São Paulo. Departamento de Cirurgia e Anatomia Faculdade de Medicina de Ribeirão Preto. Laboratório de Cirurgia Experimental Fetal e Neonatal "Michael Harrison" Divisão de Cirurgia Pediátrica. Ribeirão Preto. BR
  • Sbragia, L; Universidade de São Paulo. Departamento de Cirurgia e Anatomia Faculdade de Medicina de Ribeirão Preto. Laboratório de Cirurgia Experimental Fetal e Neonatal "Michael Harrison" Divisão de Cirurgia Pediátrica. Ribeirão Preto. BR
Braz. j. med. biol. res ; 51(5): e7132, 2018. graf
Article in English | LILACS | ID: biblio-889081
ABSTRACT
Gastroschisis (GS) is an abdominal wall defect that results in histological and morphological changes leading to intestinal motility perturbation and impaired absorption of nutrients. Due to its anti-inflammatory, antioxidant, and neuroprotective effects, cannabidiol (CBD) has been used as a therapeutic agent in many diseases. Our aim was to test the effect of maternal CBD in the intestine of an experimental model of GS. Pregnant rats were treated over 3 days with CBD (30 mg/kg) after the surgical induction of GS (day 18.5 of gestation) and compared to controls. Fetuses were divided into 4 groups 1) control (C); 2) C+CBD (CCBD); 3) gastroschisis (G), and 4) G+CBD (GCBD). On day 21.5 of gestation, the fetuses were harvested and evaluated for a) body weight (BW), intestinal weight (IW), and IW/BW ratio; b) histometric analysis of the intestinal wall; c) immunohistochemically analysis of inflammation (iNOS) and nitrite/nitrate level. BW GCBD was lower than CCBD (P<0.005), IW and IW/BW ratio GCBD was smaller than G (P<0.005), GCBD presented lower thickness in all parameters compared to G (P<0.005), iNOS and nitrite/nitrate were lower concentration in GCBD than to G (P<0.005). Maternal use of CBD had a beneficial effect on the intestinal loops of GS with decreased nitrite/nitrate and iNOS expression.
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Full text: Available Index: LILACS (Americas) Main subject: Cannabidiol / Gastroschisis / Enteritis / Fetal Diseases / Intestines / Anti-Inflammatory Agents Limits: Animals / Pregnancy Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Cannabidiol / Gastroschisis / Enteritis / Fetal Diseases / Intestines / Anti-Inflammatory Agents Limits: Animals / Pregnancy Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR