Your browser doesn't support javascript.
loading
Removal and killing of multispecies endodontic biofilms by N-acetylcysteine
Choi, Young-Suk; Kim, Cheul; Moon, Ji-Hoi; Lee, Jin-Yong.
  • Choi, Young-Suk; Kyung Hee University. School of Dentistry. Institute of Oral Biology. Seoul. KR
  • Kim, Cheul; Kyung Hee University. School of Dentistry. Institute of Oral Biology. Seoul. KR
  • Moon, Ji-Hoi; Kyung Hee University. School of Dentistry. Institute of Oral Biology. Seoul. KR
  • Lee, Jin-Yong; Kyung Hee University. School of Dentistry. Institute of Oral Biology. Seoul. KR
Braz. j. microbiol ; 49(1): 184-188, Jan.-Mar. 2018. tab, graf
Article in English | LILACS | ID: biblio-889206
ABSTRACT
ABSTRACT Removal of bacterial biofilm from the root canal system is essential for the management of endodontic disease. Here we evaluated the antibacterial effect of N-acetylcysteine (NAC), a potent antioxidant and mucolytic agent, against mature multispecies endodontic biofilms consisting of Actinomyces naeslundii, Lactobacillus salivarius, Streptococcus mutans and Enterococcus faecalis on sterile human dentin blocks. The biofilms were exposed to NAC (25, 50 and 100 mg/mL), saturated calcium hydroxide or 2% chlorhexidine solution for 7 days, then examined by scanning electron microscopy. The biofilm viability was measured by viable cell counts and ATP-bioluminescence assay. NAC showed greater efficacy in biofilm cell removal and killing than the other root canal medicaments. Furthermore, 100 mg/mL NAC disrupted the mature multispecies endodontic biofilms completely. These results demonstrate the potential use of NAC in root canal treatment.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Acetylcysteine / Streptococcus mutans / Actinomyces / Enterococcus faecalis / Biofilms / Dental Pulp Diseases / Ligilactobacillus salivarius / Anti-Bacterial Agents Limits: Humans Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2018 Type: Article / Project document Affiliation country: South Korea Institution/Affiliation country: Kyung Hee University/KR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Acetylcysteine / Streptococcus mutans / Actinomyces / Enterococcus faecalis / Biofilms / Dental Pulp Diseases / Ligilactobacillus salivarius / Anti-Bacterial Agents Limits: Humans Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2018 Type: Article / Project document Affiliation country: South Korea Institution/Affiliation country: Kyung Hee University/KR