Phage therapy: progress in pharmacokinetics
Braz. J. Pharm. Sci. (Online)
;
54(1): e17093, 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-889446
ABSTRACT
ABSTRACT The concept of phage therapy exists in the history and it has been ignored for a long time, but the consequence of drug resistance in pathogen bacteria has forced the forgotten kingdom of phage therapy to be re-explored. However, for the successful implementation and acceptance of phage therapy worldwide, the number of factors need to be addressed. In pharmacology of phage therapy, pharmacodynamics is a straightforward concept, on the other hand, owing to the unique feature of phages to replicate and their high sensitivity, pharmacokinetics is rather complex. In this review, we have discussed pharmacokinetics and some recent advances in delivery systems as to achieve the therapeutically effective concentrations of phage in their activated form.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Therapeutics
/
Bacteriophages
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2018
Type:
Article
Affiliation country:
Pakistan
Institution/Affiliation country:
Bahauddin Zakariya University/PK
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